 | | Vol. 15.15 – 28 April, 2023 |
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| The bispecific PD1-IL2v is a PD-1-targeted interleukin-2 variant (IL-2v) immunocytokine with engineered IL-2 cis targeted to PD-1 and abolished IL-2Rα binding, which enhanced tumor-antigen-specific T cell activation, while reducing regulatory Treg suppression.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that GPR84 was prominently expressed on myeloid-derived suppressor cells in clinical samples and tumor mouse models, which drove the immunosuppression on CD8+T cells by inhibiting PD-L1 degradation in lysosomes.
[Signal Transduction And Targeted Therapy] |
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| Using a mouse model of lung fibrosis, scientists demonstrated that the instillation of antibodies targeting the endogenous protein periplakin, mimicking naturally occurring autoantibodies seen in patients, directly to the lung increased lung injury, inflammation, collagen and fibronectin expression.
[European Respiratory Journal] |
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| The reserved tumor antigens and endogenous danger signals in the hybrid nanovaccine activated antigen presenting cells elicited a robust T cell response, and displayed good therapeutic efficacy in a mouse model of head and neck squamous cell carcinoma.
[Advanced Science] |
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| Scientists described a pivotal role of γδ T lymphocytes and IL-22 in the colon epithelium microenvironment, as the inulin diet failed to induce epithelium remodeling in mice lacking this T cell population or cytokine, highlighting their importance in the diet-microbiota-epithelium-immune system crosstalk.
[Microbiome] |
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| Researchers developed an active immunotherapy for personalized treatment based on a smart nanovesicle. This was achieved by anchoring membrane-bound bioactive interleukin 2 (IL2) and enriching T cell–promoting costimulatory factors on the surface of the dendritic cell–derived small extracellular vesicles.
[Science Advances] |
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| Scientists showed that the vascular destabilizing factor angiopoietin-2 caused compromised vascular integrity in the tumor periphery, leading to impaired T cell infiltration to the tumor core.
[Cancer Research] |
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| Systemic administration of mWTX-330 in mice was well tolerated, resulted in robust antitumor immunity in multiple tumor models, and preferentially activated tumor-infiltrating immune cells rather than immune cells present in peripheral tissues.
[Cancer Immunology Research] |
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| Researchers reported potent CD4 T cell-mediated tumor regression and memory responses in humanized immune system mice implanted with HT-29 colorectal tumors.
[Communications Biology] |
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| Scientists outline hallmarks of innate lymphoid cells and innate-like T cells and discuss their emerging role in antitumour immunity, as well as the pathophysiological adaptations leading to their pro-tumorigenic function.
[Nature Reviews Cancer] |
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| The authors summarize recent advances in engineering Treg cells, including the concept of biosensors for inflammation, and assess Treg cell engineering possibilities for novel functional units, including Treg cell modifications influencing stability, migration, and tissue adaptation.
[Trends In Immunology] |
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| Arbutus Biopharma Corporation announced that they were notified via verbal communication from the US FDA that the AB-101 Investigational New Drug (IND) application has been placed on clinical hold.
[Arbutus Biopharma Corp.] |
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| The patent covers treatment with an immunotherapy that targets a neoantigen predicted to be presented by a human leukocyte antigen (HLA) allele that has not been lost in a tumor, where loss of HLA alleles is determined using a proprietary sequence-based method.
[Achilles Therapeutics plc] |
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| May 28 – 31, 2023
Vancouver, British Columbia, Canada |
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| | VIB-KU Leuven Center for Cancer Biology – Leuven, Belgium |
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| | The University of Southern California – Los Angeles, California, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Dana-Farber Cancer Institute and Harvard Medical School – Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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