Immune Regulation News Volume 15.16 | May 5 2023

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    Laurisa Dohm
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    2023-05-05 | IRN 15.16


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.16 – 5 May, 2023
    TOP STORY

    Targeting PD-L2–RGMb Overcomes Microbiome-Related Immunotherapy Resistance

    The authors showed that the gut microbiome downregulated programmed death ligand (PD-L) 2 expression and its binding partner repulsive guidance molecule b (RGMb) to promote anti-tumor immunity, and identified bacterial species that mediated this effect.
    [Nature]

    AbstractPress Release
    Which Immune cell Are You?
    PUBLICATIONSRanked by the impact factor of the journal

    M Cell Maturation and cDC Activation Determine the Onset of Adaptive Immune Priming in the Neonatal Peyer’s Patch

    Researchers analyzed mononuclear phagocytes in small intestinal Peyer’s patches, the primary inductive site of intestinal immunity.
    [Immunity]

    Full ArticleGraphical Abstract

    Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment Informs New Combination Cancer Therapy Strategies

    To elucidate tumoral Treg cell ‘connectivity’ to diverse tumor-supporting accessory cell types, scientists explored immediate early changes in their single-cell transcriptomes upon punctual Treg cell depletion in experimental lung cancer and injury-induced inflammation.
    [Nature Immunology]

    Full Article

    Bcl11b Sustains Multipotency and Restricts Effector Programs of Intestinal-Resident Memory CD8+ T Cells

    Conditional deletion of Bcl11b resulted in increased numbers of intestinal intestinal-resident memory CD8+ T cells and their precursors, as well as decreased splenic effector and circulating memory cells and precursors.
    [Science Immunology]

    Abstract

    SEL1L–HRD1 Endoplasmic Reticulum-Associated Degradation Controls STING-Mediated Innate Immunity by Limiting the Size of the Activable STING Pool

    SEL1L or HRD1 deficiency in macrophages specifically amplified stimulator of interferon genes (STING) signaling and immunity against viral infection and tumor growth.
    [Nature Cell Biology]

    Full Article

    Osteoprogenitor-GMP Crosstalk Underpins Solid Tumor-Induced Systemic Immunosuppression and Persists after Tumor Removal

    Scientists characterized breast and lung cancer-induced bone marrow ecosystem shifts pre- and post-tumor removal. Remote tumors progressively led to osteoprogenitor expansion, hematopoietic stem cell dislocation, and CD41− granulocyte-monocyte progenitor aggregation.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Targeting IRG1 Reverses the Immunosuppressive Function of Tumor-Associated Macrophages and Enhances Cancer Immunotherapy

    Tumor cells induced immune-responsive gene 1 (IRG1) expression in macrophages by activating NF-κB pathway, and itaconic acids produced by aconitate decarboxylase inhibited TET DNA dioxygenases to dampen the expression of inflammatory genes and the infiltration of CD8+ T cells into tumor sites.
    [Science Advances]

    Full Article

    Termination of STING Responses Is Mediated via ESCRT-Dependent Degradation

    Investigators utilized a proteomics-based approach to assess phosphorylation changes in primary murine macrophages following stimulator of interferon genes (STING) activation.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    The PRAK-NRF2 Axis Promotes the Differentiation of Th17 Cells by Mediating the Redox Homeostasis and Glycolysis

    Researchers revealed that the P38 regulated/activated protein kinase (PRAK)-NF-E2-related factor 2 (NRF2) axis was essential for maintaining the intracellular redox homeostasis of T helper 17 (Th17) cells, thereby promoting Th17 cell differentiation and antitumor effects.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract
    Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.
    REVIEWS

    Early-Life Interactions between the Microbiota and Immune System: Impact on Immune System Development and Atopic Disease

    The authors detail the progression of immune system and microbiota maturation in early life, highlight the mechanistic links between microbes and the immune system, and summarize the role of early-life host–microorganism interactions in allergic disease development.
    [Nature Reviews Immunology]

    Abstract

    The RNA Polymerase III–RIG-I Axis in Antiviral Immunity and Inflammation

    Scientists summarize the newly emerging role of viral and host-derived RNA polymerase III transcripts in immunity, and also highlight recent advances in understanding how mammalian cellsA prevent unwanted immune activation by these RNAs to maintain homeostasis.
    [Trends In Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Immatics Announces First Bristol Myers Squibb Opt-in of TCR-T Candidate from Ongoing Multi-target Strategic Collaboration

    Immatics N.V. announced that Bristol Myers Squibb has exercised its option and entered into an exclusive worldwide license for the first T cell receptor engineered T cell therapy candidate from their ongoing collaboration.
    [Immatics N.V.]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Celiac Disease

    California Institute of Technology – Pasadena, California, United States

    Postdoctoral Positions – Cancer 3D Genome

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Research/Senior Scientist – Oncology Drug Discovery Biotherapeutics

    Novartis – Cambridge, Massachusetts, United States

    Staff Scientist – Molecular and Cellular Mechanisms of Breast Cancer Initiation

    Baylor College of Medicine – Houston, Texas, United States

    Assistant/Associate Professor – Immunity and Inflammation

    Rutgers New Jersey Medical School – Newark, New Jersey, United States

    > See All Jobs

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