 | | Vol. 15.17 – 12 May, 2023 |
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| Scientists reported that CD8+ T cells displayed B7 ligands that interacted with CD28 in cis at membrane invaginations of the immunological synapse as a result of membrane remodeling driven by phosphoinositide-3-kinase and sorting-nexin-9.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers exploited differences between inbred mouse strains to identify an epithelium-intrinsic mechanism that regulated tuft cell differentiation and tunes innate type 2 immunity in the small intestine.
[Science Immunology] |
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| The authors found that the engulfment of apoptotic cells triggered homeostatic maturation of type 1 conventional DCs (cDC1s) within the spleen, and that this process could be mimicked by engulfment of empty, nonadjuvanted lipid nanoparticles.
[Science Immunology] |
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| Investigators described a microglial subtype expressing the enzyme arginase-1 that was found predominantly in the basal forebrain and ventral striatum during early postnatal mouse development.
[Nature Neuroscience] |
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| When the authors mimicked an early systemic viral infection or applied murine cytomegalovirus systemically in neonatal female and male mice, only male adolescent mice presented behavioral deficits, including reduced social behavior and cognition.
[Nature Communications] |
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| Within the highly proliferative neighborhood, scientists found out that TREM2+ skin cancer-associated macrophages supported the proliferation of a distinct tumor epithelial population through an immunosuppression-independent manner via oncostatin-M/JAK-STAT3 signaling.
[Nature Communications] |
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| Researchers revealed a unique group 2 innate lymphoid cells (ILC2) subset in the mouse intestine that constitutively expressesed IL-4 together with GATA3, ST2, KLRG1, IL-17RB, and IL-5.
[Journal Of Experimental Medicine] |
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| Investigators systematically examined the adjuvant activity, route of administration, and antigen-specific immunity of circular RNAs vaccination in mice.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists generated anti-human-T cell immunoreceptor with Ig and ITIM domains (TIGIT) agonistic monoclonal antibodies (mAbs) and generated human-TIGIT knock-in mice to accurately evaluate the efficacy of mAb function.
[Communications Biology] |
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| Innate immunity plays an instrumental role in the induction of adaptive antiviral immunity. The authors review how inborn errors of innate immunity can instigate B cell autoimmunity.
[Science] |
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| Scientists provide updates on our understanding of the longevity, functional heterogeneity, differentiation, plasticity, migration, and human immunodeficiency virus reservoirs as well as key technological advances that are facilitating the characterization of memory CD4+ T cell biology.
[Nature Immunology] |
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| The authors discuss recent evidence suggesting a bi-directional link between the genetic architecture of individuals and maternal activation of the immune system in modulating brain developmental trajectories in health and disease.
[EMBO Journal] |
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| South Korea-based Daewoong Pharmaceutical has signed a Global License Agreement for its autoimmune disease drug candidate DWP213388 with Vitalli Bio, a US biotechnology company.
[Daewoong Pharma (BioSpectrum Asia)] |
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| June 12 – 15, 2023
EMBL Heidelberg and Virtual |
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| | NCI Center for Cancer Research – Frederick, Maryland, United States |
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| | KU Leuven – Leuven, Belgium |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | Calico Life Sciences LLC – San Francisco, California, United States |
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| | California Institute of Technology – Pasadena, California, United States |
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