 | | Vol. 15.20 – 2 June, 2023 |
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| Mathematical modeling identified a highly connected multi-enhancer hub at the Ets1 locus, comprising a noncoding regulatory element that was a hotspot for sequence variation associated with allergic disease in humans.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that T follicular helper (TFH) cell localization was critical for the quality of the antibody response and for the expansion of the follicular dendritic cell network upon immunization.
[Nature Immunology] |
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| Cerebrovascular repair did not occur in interluekin (IL)-6 knockouts or in mice lacking microglial IL-6Ra expression, and single-cell transcriptomic analyses revealed faulty repair-associated microglia programming in the absence of IL-6 signaling.
[Nature Immunology] |
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| Researchers identified preferential activation and enhanced suppressive capacity of regulatory T cells in αPD-L1 therapy–resistant solid tumor–bearing mice.
[Science Immunology] |
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| Following pulmonary immunization with a Salmonella vaccine strain, mouse MAIT cells expanded as separate CD127−Klrg1+ and CD127+Klrg1− antigen-adapted populations that differed in terms of their transcriptome, function and localization in lung tissue.
[Nature Cell Biology] |
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| Treg cells administered through perforated microneedle substantially ameliorated psoriasis syndrome with the assistance of fatty acid–mediated metabolic intervention in a psoriasis mouse model.
[Science Advances] |
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| Using an aggressive E0771 mouse breast cell line syngeneic immune-intact murine model, scientists observed that breast tumors were “permanently eradicated” in a genetically engineered tamoxifen-inducible Treg-cell-specific SRC-3 knockout female mouse that did not possess a systemic autoimmune pathological phenotype.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Conditional ablation of Mettl3 in CD4+CD8+ double-positive thymocytes impaired invariant natural killer T cell proliferation, differentiation, and cytokine secretion.
[Cell Reports] |
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| Researchers demonstrated that inducible and simultaneous ablation of transcription factor-encoding Ovol1 and Ovol2 in adult epidermis results in barrier dysregulation through impacting epithelial-mesenchymal plasticity and inflammatory gene expression.
[EMBO Reports] |
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| The authors present an overview of inflammasome pathways, outlining the mechanisms of inflammasome formation, subcellular regulation, and pyroptosis, and discuss the wide-reaching effects of inflammasomes in human disease.
[Cell] |
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| The Council has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.
[Council of the European Union] |
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| Thousands of early-career researchers at the US National Institutes of Health (NIH) have kick-started the process of forming a union. They are calling on the agency to raise pay and improve benefits, as well as to bolster its policies and procedures on harassment and excessive workloads.
[Nature News] |
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| IGM Biosciences, Inc. announced that the FDA has cleared two Investigational New Drug applications for imvotamab, an IgM-based CD20 X CD3 bispecific antibody T cell engager, enabling the initiation of Phase Ib studies in both severe systemic lupus erythematosus and severe rheumatoid arthritis.
[IGM Biosciences, Inc.] |
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| June 28 – 30, 2023
Shanghai, China |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Brown University – Providence, Rhode Island, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | NCI Center for Cancer Research – Frederick, Maryland, United States |
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