 | | Vol. 15.21 – 9 June, 2023 |
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| The authors showed that agonists of α2-adrenergic receptors (α2-AR) had very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumor models, including immunecheckpoint blockade-resistant models, but not in immunodeficient models.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To better understand transcriptional regulation of T helper 2 cell differentiation, researchers performed CRISPR-Cas9 screens targeting 1,131 transcription factors. They discovered that activity-dependent neuroprotector homeobox protein was indispensable for immune reactions to allergen.
[Immunity] |
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| Through single cell transcriptomics, investigators identified a population of tumor-associated macrophages that expressed a unique array of pro-tumorigenic senescence-associated secretory phenotype factors and surface proteins and were also present in normal aged lungs.
[Cancer Cell] |
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| Researchers established an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline to define the transcriptome and global phosphoproteome of blood-induced innate immune polarization and its role in microglia neurotoxicity.
[Nature Immunology] |
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| The presence of concomitant colon tumors improved control of liver lesions by anti–PD-L1 proof-of-concept immunotherapy and generated protective immune memory, whereas partial depletion of α4β7+ cells abrogated control of metastases.
[Science Immunology] |
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| Growth hormone releasing hormone receptor activated the JAK-STAT3 pathway, increased the phosphorylation of STAT3, enhanced both non-pathogenic and pathogenic Th17 cell differentiation, and promoted the gene expression signatures of pathogenic Th17 cells.
[Nature Communications] |
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| In vitro and in vivo experiments were performed to elucidate the function and potential mechanisms of small extracellular vesicle microRNAs that contributed to the development of Hashimoto’s thyroiditis.
[BMC Medicine] |
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| Scientists reported that interleukin-3 (IL-3)-deficient mice were more susceptible and exhibited increased intestinal inflammation during the early stage of experimental colitis.
[Cell Reports] |
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| Mechanistically, Altre interacted with Yin Yang 1 to orchestrate its occupation on chromatin, thereby regulating the expression of a group of mitochondrial genes, and maintaining optimal mitochondrial function and Treg fitness in the liver of aged mice.
[Nature Aging] |
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| Scientists discuss inflammaging at the molecular, cellular, organ, and disease levels, and review current aging models, the implications of cutting-edge single cell technologies, as well as anti-aging strategies.
[Signal Transduction And Targeted Therapy] |
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| The authors discuss the newer concepts of regulation of monocyte homeostasis and function by gut microbial signals during steady state and inflammation, and highlight the therapeutic potential of microbial signal-based approaches for modulation in the context of various diseases.
[Trends In Microbiology] |
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| Under the terms of the agreement, Quell’s proprietary toolbox of Treg cell engineering modules, including its Foxp3 Phenotype Lock, will be leveraged to develop autologous multi-modular Treg cell therapy candidates for Type 1 Diabetes and Inflammatory Bowel Disease.
[Quell Therapeutics Ltd.] |
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| June 26 – 29, 2023
Boston, Massachusetts, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | UMass Chan Medical School – Worcester, Massachusetts, United States |
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| | NCI Center for Cancer Research – Frederick, Maryland, United States |
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