Immune Regulation News Volume 15.22 | Jun 16 2023

June 16, 2023

2023-06-16 | IRN 15.22

Immune Regulation News by STEMCELL Technologies

Vol. 15.22 – 16 June, 2023

TOP STORY

A Microbiota-Modulated Checkpoint Directs Immunosuppressive Intestinal T Cells Into Cancers

Enterocloster species that recolonized the guts of mice treated with antibiotics down-regulated the expression of MAdCAM-1, the ligand for integrin α4β7 that helps to retain an immunosuppressive subset of T cells within the gut.
[Science]

Abstract Graphical Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Identification of an IL-1 Receptor Mutation Driving Autoinflammation Directs IL-1-Targeted Drug Design

Mice with a homologous mutation exhibited hyperinflammation and greater susceptibility to collagen antibody-induced arthritis, accompanied with pathological osteoclastogenesis. Scientists leveraged this to design an IL-1 therapeutic, which trapped IL-1β and IL-1α, but not IL-1Ra.
[Immunity]

Abstract Graphical Abstract

A Subpopulation of CD146⁺ Macrophages Enhances Antitumor Immunity by Activating the NLRP3 Inflammasome

The authors identified a subpopulation of CD146⁺ tumor-associated macrophages that exerted antitumor activity in both human samples and animal models.
[Cellular & Molecular Immunology]

Full Article

Single Cell and Spatial Sequencing Define Processes by Which Keratinocytes and Fibroblasts Amplify Inflammatory Responses in Psoriasis

Researchers demonstrated, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occurred within the supraspinous layer of the psoriatic epidermis.
[Nature Communications]

Full Article

CD8⁺ T Cell Depletion Prevents Neuropathology in a Mouse Model of Globoid Cell Leukodystrophy

Administration of a function-blocking antibody against CD8α effectively prevented disease onset, reduced morbidity and mortality, and prevented central nervous system demyelination in mice.
[Journal Of Experimental Medicine]

Full Article

Bioengineered Particles Expand Myelin-Specific Regulatory T Cells and Reverse Autoreactivity in a Mouse Model of Multiple Sclerosis

Tolerogenic microparticles were validated in vitro and then evaluated in a mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis.
[Science Advances]

Full Article Press Release

Therapy Targeting Antigen-Specific T Cells by a Peptide-Based Tolerizing Vaccine against Autoimmune Arthritis

Scientists showed that the administration of exogenous mouse major histocompatibility complex class II protein bounding a unique galactosylated collagen type II peptide directly interacted with the antigen-specific T cell receptor through a positively charged tag.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]

Abstract

Attenuation of OX40 Signaling Suppression by Age Disrupts Peripheral Deletion of CD4⁺ T Cells Specific for the Epidermal Autoantigen Desmoglein 3

Researchers used CD4⁺ T cells expressing a transgenic T cell receptor specific for desmoglein 3, which is the target antigen of the autoimmune bullous disease pemphigus vulgaris, to examine how peripheral immunological tolerance against pathogenic autoreactive CD4⁺ T cells changed with age.
[Immunity & Ageing]

Full Article

ACSL1 Is a Key Regulator of Inflammatory and Macrophage Foaming Induced by Short-Term Palmitate Exposure or Acute High-Fat Feeding

Oral administration of acyl-CoA synthetase-1 (ACSL1) inhibitor triacsin-C in mice before acute-high-fat feeding normalized the inflammatory/foamy phenotype of the circulatory monocytes by suppressing FABP4 expression.
[iScience]

Abstract Full Article Graphical Abstract

Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.

REVIEWS

Regulatory T Cells in the Face of the Intestinal Microbiota

Scientists review new information that has appeared in recent years on the diversity of Tregs, the importance of the transcription factor FOXP3, how T cell receptors influence their fate, and the unexpected and varied cellular partners that influence Treg cell homeostatic setpoints.
[Nature Reviews Immunology]

Abstract

Regulation of Systemic Metabolism by Tissue-Resident Immune Cell Circuits

The authors review the evidence describing key cellular networks within and between the liver, gastrointestinal tract, and adipose tissue that control systemic metabolism and how these cell circuits become dysregulated during certain metabolic diseases.
[Immunity]

Full Article

INDUSTRY AND POLICY NEWS

Mozart Therapeutics Raises $25 Million in Expanded Series A Financing to Support Clinical Development of First-in-Class CD8 Treg Modulators for the Treatment of Autoimmune Diseases

Mozart is developing a portfolio of CD8 Treg Modulators including MTX-101, a bispecifc autoimmune checkpoint inhibitor, for the treatment of autoimmune diseases. The company anticipates filing an investigational new drug and initiating a Phase I clinical trial for MTX-101 in early 2024.
[Mozart Therapeutics]

Press Release

FEATURED EVENT

Immune Regulation News Volume 15.22 | Jun 16 2023

A Microbiota-Modulated Checkpoint Directs Immunosuppressive Intestinal T Cells Into Cancers

Identification of an IL-1 Receptor Mutation Driving Autoinflammation Directs IL-1-Targeted Drug Design

A Subpopulation of CD146⁺ Macrophages Enhances Antitumor Immunity by Activating the NLRP3 Inflammasome

Single Cell and Spatial Sequencing Define Processes by Which Keratinocytes and Fibroblasts Amplify Inflammatory Responses in Psoriasis

CD8⁺ T Cell Depletion Prevents Neuropathology in a Mouse Model of Globoid Cell Leukodystrophy

Bioengineered Particles Expand Myelin-Specific Regulatory T Cells and Reverse Autoreactivity in a Mouse Model of Multiple Sclerosis

Therapy Targeting Antigen-Specific T Cells by a Peptide-Based Tolerizing Vaccine against Autoimmune Arthritis

Attenuation of OX40 Signaling Suppression by Age Disrupts Peripheral Deletion of CD4⁺ T Cells Specific for the Epidermal Autoantigen Desmoglein 3

ACSL1 Is a Key Regulator of Inflammatory and Macrophage Foaming Induced by Short-Term Palmitate Exposure or Acute High-Fat Feeding

Regulatory T Cells in the Face of the Intestinal Microbiota

Regulation of Systemic Metabolism by Tissue-Resident Immune Cell Circuits

Mozart Therapeutics Raises $25 Million in Expanded Series A Financing to Support Clinical Development of First-in-Class CD8 Treg Modulators for the Treatment of Autoimmune Diseases

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Postdoctoral Researcher – Rheumatoid Arthritis & Chronic Inflammatory Diseases

Group Leader – Fibrosis and Wound Healing

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