 | | Vol. 15.23 – 23 June, 2023 |
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| Using high-throughput flow cytometry as well as bulk and ssRNA-sequencing and B cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, scientists identified a subset of B cells that expanded specifically in the draining lymph node over time in tumor-bearing mice.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| An M2 macrophage-erythrocyte hybrid membrane-camouflaged biomimetic nanosized liposome was engineered to deliver targeted self-cascading bienzymes and immunomodulators to reprogram the inflammatory microenvironment in gouty rats.
[Advanced Materials] |
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| Investigators identified a population of pulmonary dendritic cells that expressed intermediate levels of CD103 and appeared in the lungs and lung-draining lymph nodes of mice between birth and two weeks of age.
[Science Immunology] |
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| Researchers reported that multiple canonical activators of NLRP3 in mouse macrophages shared the ability to displace the glycolytic enzyme hexokinase 2 from the voltage-dependent anion channel (VDAC) on the outer membranes of mitochondria.
[Science Immunology] |
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| After restricting the N-glycosylation profile of thymocytes to high-mannose structures, using specific glycoengineered mice, scientists showed remarkable defects in key developmental checkpoints, including ß-selection, regulatory T cell generation, and γδT cell development.
[Cellular & Molecular Immunology] |
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| The block of innate natural killer T cells (iNKT) cell development in the absence of Tnpo3 could be overcome by transgenic provision of a rearranged Trav11-Traj18-Trac cDNA, indicating that Tnpo3 deficiency did not interfere with the development of iNKT cells per se.
[Nature Communications] |
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| Inhibition of CD103 in uninflamed skin did not alter Treg behavior, whereas 48 hours after inducing contact hypersensitivity by oxazolone challenge, CD103 inhibition increased Treg migration.
[Journal Of Immunology] |
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| The authors established an experimental autoimmune uveitis model by immunizing mice with interphotoreceptor retinoid-binding protein 651–670.
[Cellular Immunology] |
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| Understanding the imprinting of Treg cell identity and specialized function will be key to unravelling basic mechanisms of autoimmunity and identifying novel targets for drug development.
[Nature Reviews Immunology] |
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| Scientists discuss recent progress in our understanding of eosinophil activities within tissues, with particular emphasis on the gastrointestinal tract, where a large population of these cells resides under non-inflammatory conditions.
[Journal Of Experimental Medicine] |
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| The authors dissect the role played by the immune system in the endometrial–embryo crosstalk, with a particular emphasis towards the fork-head-box-p3 CD4+CD25+ Treg cells, and discuss the most recent therapeutic advances in the context of early immune-mediated pregnancy loss.
[Trends In Molecular Medicine] |
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| The new patent claims cover Silo Pharma, Inc.’s portfolio drug SPU-21, a peptide-guided anti-arthritis drug, as a method of selectively targeting inflamed synovial tissue.
[Silo Pharma, Inc.(GlobeNewswire)] |
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| July 7 – 8, 2023
Montréal, Québec, Canada |
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| | University of Miami – Miami, Florida, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | King’s College London – London, England, United Kingdom |
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| | BioMed X – Ridgefield, Connecticut, United States |
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| | Karolinska Institutet – Solna, Sweden |
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