Immune Regulation News Volume 15.25 | Jul 7 2023

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    Laurisa Dohm
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    2023-07-07 | IRN 15.25


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.25 – 7 July, 2023
    TOP STORY

    SLC38A2 and Glutamine Signaling in cDC1s Dictate Anti-Tumor Immunity

    Researchers established glutamine as an intercellular metabolic checkpoint that dictated tumor–type-1 conventional dendritic cell crosstalk, and licensed their function in activating cytotoxic T cells.
    [Nature]

    Full ArticlePress Release
    GI Organoid Applications
    PUBLICATIONSRanked by the impact factor of the journal

    CXCR3 Expression in Regulatory T Cells Drives Interactions with Type I Dendritic Cells in Tumors to Restrict CD8+ T Cell Antitumor Immunity

    Genetic ablation of CXCR3 in Treg cells disrupted dendritic cell (DC) 1-Treg cell interactions, and concomitantly increased DC-CD8+ T cell interactions.
    [Immunity]

    AbstractGraphical Abstract

    Single-Cell Protein Expression Profiling Resolves Circulating and Resident Memory T Cell Diversity across Tissues and Infection Contexts

    The authors utilized an antibody screening platform and machine learning prediction pipeline to profile >200 proteins in circulating and tissue-resident memory T cells in solid organs and barrier locations.
    [Immunity]

    AbstractGraphical Abstract

    Multivalent Tyrosine Kinase Inhibition Promotes T Cell Recruitment to Immune-Desert Gastric Cancers by Restricting Epithelial-Mesenchymal Transition via Tumor-Intrinsic IFN-γ Signaling

    Bioinformatics, human and mouse gastric cancer (GC) cell lines, syngeneic murine gastric tumor model, and CTLA4 blockade were used to investigate the immunotherapeutic effects by restricting receptor tyrosine kinase signaling in immune desert type GC.
    [Gut]

    Abstract

    Measuring Anti-Islet Autoimmunity in Mouse and Human by Profiling Peripheral Blood Antigen-Specific CD4 T Cells

    Peptide–major histocompatibility complex tetramers were used to profile blood anti-insulin CD4 T cells in mice and humans. The state of activation of anti-insulin T cells measured by RNA and protein profiling was able to distinguish the absence of autoimmunity vs. disease progression.
    [Science Translational Medicine]

    Full Article

    Dysregulated IFN-γ Signals Promote Autoimmunity in STAT1 Gain-of-Function Syndrome

    To dissect underlying immune mechanisms, researchers generated Stat1 gain-of-function transgenic mice and confirmed the development of spontaneous humoral autoimmunity that recapitulated the human phenotype.
    [Science Translational Medicine]

    Abstract

    Nanoparticles Hitchhike on Monocytes for Glioblastoma Treatment after Low-Dose Radiotherapy

    Scientists synthesized nanoparticles that hitchhiked on circulating monocytes to target intracranial glioblastomas with the assistance of low-dose radiotherapy.
    [ACS Nano]

    AbstractGraphical Abstract

    Toll-Like Receptor Mediated Inflammation Directs B Cells towards Protective Antiviral Extrafollicular Responses

    Investigators found that inflammatory signals acted as B cell fate-determinants for the rapid generation of protective antiviral extrafollicular responses.
    [Nature Communications]

    Full Article

    Diesel Exhaust Particle (DEP)-Induced Glucose Intolerance Is Driven by an Intestinal Innate Immune Response and NLRP3 Activation in Mice

    Oral exposure to air pollution particles induced an interferon and inflammatory signature in colon macrophages together with a decrease of CCR2− anti-inflammatory/resident macrophages.
    [Particle And Fibre Toxicology]

    Full Article
    The STEMdiff™ Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.
    REVIEWS

    Regulatory T Cells in Autoimmune Kidney Diseases and Transplantation

    Scientists discuss the roles of Tregs in autoimmune kidney diseases and transplantation, as well as their roles more generally in autoimmune disorders and inflammatory diseases.
    [Nature Reviews Nephrology]

    Abstract

    Neutrophil Diversity and Plasticity: Implications for Organ Transplantation

    The authors discuss the heterogeneity and role of neutrophils in solid organ transplantation and how neutrophils may contribute to transplant-related complications.
    [Cellular & Molecular Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Kyverna Therapeutics Announces Regulatory Approval of Phase I/II Clinical Trial for KYV-101 in Germany

    KYV 101 is a novel therapy for the treatment of lupus nephritis; a fully human anti-CD19 chimeric antigen receptor T cell therapy for use in B cell-driven autoimmune diseases.
    [Kyverna Therapeutics]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    PhD Position – Models of Motor Neuron Degeneration

    National Institutes of Health – Houston, Texas, United States

    Postdoctoral Researcher – Inflammatory Conditions

    Maynooth University – Maynooth, Ireland

    PhD positions – Computational Immunology

    Charité Berlin – Berlin, Germany

    Postdoctoral Associate – Tumor Virus & Innate Immunity

    University of Miami – Miami, Florida, United States

    Postdoctoral Researcher – Rheumatoid Arthritis & Chronic Inflammatory Diseases

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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