 | | Vol. 15.26 – 14 July, 2023 |
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| The authors showed that antigen-specific avoidance behavior in inbred mice was critically dependent on mast cells; hence, the authors identified the immunological sensor cell linking antigen recognition to avoidance behavior.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used the minimal gene regulatory network of type 1 conventional dendritic cells to reprogram cancer cells into professional antigen-presenting cells.
[Science Immunology] |
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| Upon subcutaneous injection, nanomedicine-in-hydrogel prolonged lymph node retention of the cGAS inhibitor RU.521 and cell free DNA (cfDNA)-scavenging cationic nanoparticles, which pharmacologically inhibit cGAS and scavenged cfDNA, respectively, to inhibit proinflammation.
[Advanced Science] |
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| Mechanistically, Cathepsin W inhibited IL-2R signaling in peripheral Treg cells by cytosolic interaction with and process of CD25, repressing signal transducer and activator of transcription 5 activation to restrain peipheral Treg cell generation and maintenance.
[Science Advances] |
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| Selective depletion of Tregs showed that Tregs are protective against alopecia areata in C3H/HeJ mice, suggesting that failure of Treg-mediated immunosuppression is not a major disease mechanism in alopecia areata.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| T cell receptors (TCR) form spatiotemporally dynamic clusters to mediate robust yet temporal signaling to induce adaptive immune responses. The authors identified a phase separation mechanism controlling dynamic TCR clustering and signaling.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators studied the effect of human Thymosin-alpha-1 treatment on the immune system in population groups with different thymic function levels in the scenario of SARS-CoV2 infection.
[Immunity & Ageing] |
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| Treatment with low-dose anti-thymocyte globulin (ATG) preserved Tregs, as measured by stable methylation of FOXP3 Treg-specific demethylation region and increased proportions of CD4+FOXP3+ Tregs identified by flow cytometry.
[JCI Insight] |
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| As part of the ONE Study consortium, scientists conducted a phase I-II clinical trial in which purified donor antigen reactive-Tregs were administered to three patients, 7 to 11 days after live donor renal transplant.
[American Journal Of Transplantation] |
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| The authors review the factors affecting neuroinflammation and the major inflammatory signaling pathways involved in the pathogenicity of neurodegenerative diseases.
[Signal Transduction And Targeted Therapy] |
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| The function of cutaneous lymphocyte-associated antigen (CLA+) T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases.
[Allergy] |
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| Having paid $300 million to enter the TIGIT space by acquiring ociperlimab in 2021, Novartis is now handing the candidate back to BeiGene.
[Fierce Biotech] |
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| August 28 – 30, 2023
Santa Fe, New Mexico, United States |
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| | ShanghaiTech University – Shanghai, China |
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| | Maynooth University – Maynooth, Ireland |
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| | Charité Berlin – Berlin, Germany |
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| | Karolinska Institutet – Solna, Sweden |
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| | NCI Center for Cancer Research – Frederick, Maryland, United States |
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