 | | Vol. 15.27 – 21 July, 2023 |
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| In situ photoconversion and Prtn3-based fate-tracking revealed that the lymph node medullary cords were preferential entry sites for dendritic cell precursors, serving as specific differentiation niches.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Diet-induced obesity resulted in a reduction of PPARγ+ skin Treg cells and a corresponding loss of control over IL-17A+ γδ T cell-mediated inflammation.
[Immunity] |
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| Using reporter and knockout mouse models combined with single-cell RNA-sequencing, progenitor transfer and colony assays, investigators showed that the transcription factor ThPOK controlled monocyte-dendritic cell versus granulocyte lineage production during homeostatic differentiation.
[Nature Immunology] |
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| Researchers reported a nano-mediated strategy to stimulate the precise clearance of activated neutrophils initiated with artificial aged signal and alleviated inflammation.
[ACS Nano] |
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| Mice deficient in cellular inhibitor of apoptosis proteins 1 and 2 (cIAP1/2) had severely reduced γδT17 cells and group 3 innate lymphoid cells (ILC3), presented with suboptimal γδT17 responses in the skin, lacked intestinal isolated lymphoid follicles, and could control intestinal bacterial infection.
[Journal Of Experimental Medicine] |
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| The authors combined whole-tissue imaging and single-cell RNA sequencing datasets to generate a pan-organ analysis of mast cells in mice and humans at steady state.
[Journal Of Experimental Medicine] |
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| Neutralization and knockdown of prosaposin or blocking GRP37 abrogated the pro-resolution effects of efferocyte-derived extracellular vesicles in vivo.
[Cell Reports] |
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| To determine the roles of T-bet-expressing Treg cells, scientists generated a mouse strain, called VeDTR, in which T-bet/Foxp3 double-positive cells were engineered to be specifically labeled and depleted by a combination of Cre- and Flp-recombinase-dependent gene expression control.
[Cell Reports] |
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| To determine the function of thymic stromal lymphopoietin (TSLP) in barrier sites, researchers investigated the impact of endogenous TSLP signaling on the homeostatic expansion of CD4+ T cells in adult mice.
[JCI Insight] |
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| The authors summarize the major findings that led to the discovery of RORγt+ Aantigen-presenting cells and their associated functions, discuss discordance in recent reports, and identify gaps in knowledge in this burgeoning field.
[Nature Reviews Immunology] |
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| Scientists review recent advances in the understanding of the fibrotic microenvironment in human diseases, with a focus on immune cell profiles and functional immune–stromal interactions.
[Nature Immunology] |
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| NIH and other funding agencies are putting the kibosh on the approach. NIH banned the use of online generative AI tools like ChatGPT “for analyzing and formulating peer-review critiques”.
[Science Insider] |
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| September 12 – 14, 2023
Munich, Germany |
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| | Rheinische Friedrich-Wilhelms-Universität Bonn – Bonn, Germany |
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| | ShanghaiTech University – Shanghai, China |
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| | Charité Berlin – Berlin, Germany |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Karolinska Institutet – Solna, Sweden |
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