Immune Regulation News Volume 15.28 | Jul 28 2023

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    Laurisa Dohm
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    2023-07-28 | IRN 15.28


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.28 – 28 July, 2023
    TOP STORY

    Graded Expression of the Chemokine Receptor CX3CR1 Marks Differentiation States of Human and Murine T Cells and Enables Cross-Species Interpretation

    The CX3CR1 expression gradient delineated states with comparable properties in humans and mice in steady state and on longitudinally tracked virus-specific CD8+ T cells in both species.
    [Immunity]

    Full ArticleGraphical Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Intestinal Microbiota Controls Graft-Versus-Host Disease Independent of Donor-Host Genetic Disparity

    Investigators demonstrated that genetically identical mice of differing vendor origins had markedly different intestinal microbiota and ileal MHC-II expression, resulting in discordant graft-versus-host disease severity.
    [Immunity]

    AbstractGraphical Abstract

    Cotransfer of Antigen and Contextual Information Harmonizes Peripheral and Lymph Node Conventional Dendritic Cell Activation

    Using a novel strain of influenza A and a modified melanoma model, researchers showed that tissue and lymph node conventional dendritic cell activation was harmonized, and that this was driven by cotransfer of contextual cues.
    [Science Immunology]

    Abstract

    IL-21 Shapes Germinal Center Polarization via Light Zone B Cell Selection and Cyclin D3 Upregulation

    The authors showed that IL-21, the archetypal follicular helper T cell cytokine, shaped the scale and polarization of spontaneous chronic autoimmune as well as transient immunization-induced germinal center.
    [Journal Of Experimental Medicine]

    Full Article

    Multi-Tiered Approach to Detect Autoimmune Cross-Reactivity of Therapeutic T Cell Receptors

    Scientists described a practical framework to prospectively detect clinically prohibitive cross-reactivity of therapeutic T cell receptor candidates.
    [Science Advances]

    Full Article

    T Cell Deletional Tolerance Restricts AQP4 but Not MOG CNS Autoimmunity

    When modeling neuromyelitis optica, only aquaporin-4 (AQP4)-reactive Th17 cells from AQP4-deficient, but not wild-type mice, caused central nervous system autoimmunity in recipient wildtype mice, indicating that a tightly regulated mechanism normally ensured tolerance to AQP4.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Both Intratumoral Regulatory T Cell Depletion and CTLA-4 Antagonism Are Required for Maximum Efficacy of Anti-CTLA-4 Antibodies

    Scientists reported the engineering of a nonantagonistic CTLA-4 binding domain that depleted intratumoral Tregs as an Fc fusion.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Dendritic Cell ICAM-1 Strengthens Synapses with CD8 T Cells but Is Not Required for Their Early Differentiation

    Investigators dissected the in vivo roles of endogenousdendritic cell ICAM-1 in antigen-stimulated T cell proliferation and differentiation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dual-Locus, Dual-HDR Editing Permits Efficient Generation of Antigen-Specific, Regulatory T Cells with Robust Suppressive Activity

    Researchers presented a single-step, combinatorial gene editing strategy utilizing dual-locus, dual-homology directed repair (HDR) to generate and specifically expand antigen-specific engineered Tregs derived from donor CD4+ T cells.
    [Molecular Therapy]

    AbstractGraphical Abstract
    Request your free copy of the 'Human Immune Cytokines' Wallchart
    REVIEWS

    Interleukin-17 as a Key Player in Neuroimmunometabolism

    Researchers review the emerging role of IL-17 signaling in regulating metabolic processes, which may shine a light on the evolutionary role of IL-17 beyond typical immune responses.
    [Nature Metabolism]

    Abstract

    Immune-Related Adverse Events after Immune Check Point Inhibitors: Understanding the Intersection with Autoimmunity

    Scientists address the question of whether the mechanisms that drive immune checkpoint inihibitor (ICI)-induced immune-related adverse events are shared or distinct with those driving spontaneous autoimmunity, focusing on ICI-induced diabetes, ICI-induced arthritis, and ICI-induced thyroiditis.
    [Immunological Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-Class T Cell Receptor Natural Killer (TCR-NK) Cell Therapy for Multiple Myeloma

    Replay and The University of Texas MD Anderson Cancer Center announced that the US FDA has issued a ‘safe to proceed’ for the Investigational New Drug (IND) application for NY-ESO-1 TCR/IL-15 NK, a first-in-class engineered TCR-NK cell therapy for relapsed or refractory multiple myeloma.
    [Replay Bio]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

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    Washington University – St. Louis, Missouri, United States

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    University of Connecticut Health – Farmington, Connecticut, United States

    Postdoctoral Scientist – Tumor Immunology and Radio-Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Researcher – Rheumatoid Arthritis and Chronic Inflammatory Diseases

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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