Immune Regulation News Volume 15.31 | Aug 18 2023

August 18, 2023

2023-08-18 | IRN 15.31

Immune Regulation News by STEMCELL Technologies

Vol. 15.31 – 18 August, 2023

TOP STORY

CTLA-4 Blockade Induces CD4⁺ T Cell IFNγ-Driven Microglial Phagocytosis and Anti-Tumor Function in Glioblastoma

Scientists found that treatment with αCTLA-4, but not αPD-1, prolonged survival in a mouse model of mesenchymal-like glioblastoma.
[Immunity]

Full Article

Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.

PUBLICATIONSRanked by the impact factor of the journal

Lymph Node Sharing between Pancreas, Gut, and Liver Leads to Immune Crosstalk and Regulation of Pancreatic Autoimmunity

Investigators described the drainage hierarchy of the pancreas, liver, and the upper small intestine into three murine lymph nodes.
[Immunity]

Abstract Graphical Abstract

Symbiotic Firmicutes Establish Mutualism with the Host via Innate Tolerance and Resistance to Control Systemic Immunity

Researchers uncovered host tolerance and resistance mechanisms that allowed Firmicutes from the human microbiota to control systemic immunity without inducing immunopathology.
[Cell Host & Microbe]

Full Article Graphical Abstract

Short-Term Dietary Changes Can Result in Mucosal and Systemic Immune Depression

The authors showed that short-term reiterative switching to ‘feast diets’, mimicking our social eating behavior, breached the potential buffering effect of the intestinal microbiota and reorganized the immunological architecture of mucosa-associated lymphoid tissues.
[Nature Immunology]

Full Article

CCR2 Macrophage Response Determines the Functional Outcome following Cardiomyocyte Transplantation

Scientists compared the cellular, molecular, and functional outcome following cardiomyocyte transplantation in wildtype and T cell- and B cell-deficient Rag2^del mice.
[Genome Medicine]

Full Article

Interferon-G-Dependent Interactions between Tissue-Intrinsic γδ T Cells and Tissue-Infiltrating CD8 T Cells Limit Acute Contact Dermatitis

In mice lacking dendritic intraepidermal γδ T cells or lacking IFNγR solely on γδ cells, allergic contact dermatitis (ACD)-elicited CD8 T cells showed enhanced proliferative and effector potentials and reduced motility, collectively associated with exaggerated ACD pathology.
[Journal Of Allergy And Clinical Immunology]

Abstract

MARCH5-Dependent NLRP3 Ubiquitination Is Required for Mitochondrial NLRP3-NEK7 Complex Formation and NLRP3 Inflammasome Activation

Researchers showed that NLRP3 was ubiquitinated by the mitochondria-associated E3 ligase, MARCH5.
[EMBO Journal]

Full Article Graphical Abstract

A Target-Based Discovery from a Parasitic Helminth as a Novel Therapeutic Approach for Autoimmune Diseases

Investigators carried out colitis and psoriasis models to evaluate the function of Tregs induced by helminth-derived peptide in vivo.
[Ebiomedicine]

Full Article

SOCS3 Deletion in Effector T Cells Confers an Anti-Tumorigenic Role of IL-6 to the Pro-Tumorigenic Cytokine

SOCS3 knockdown in human chimeric antigen receptor T cells exhibited a strong anti-tumor response in humanized mice.
[Cell Reports]

Full Article Graphical Abstract

This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.

REVIEWS

Food Allergen Sensitization on a Chip: The Gut–Immune–Skin Axis

The authors outline recently developed organ-on-a-chip platforms and discuss the features needed for reliable prediction of sensitizing allergenicity of proteins.
[Trends In Biotechnology]

Full Article

INDUSTRY AND POLICY NEWS

Artiva Biotherapeutics Announces FDA Clearance of IND for AlloNK^® Cell Therapy Candidate in Combination with Rituximab in Lupus Nephritis

AlloNK is a non-genetically modified, cord blood-derived, allogeneic, cryopreserved natural killer cell therapy candidate designed to enhance antibody-dependent cellular cytotoxicity.
[Artiva Biotherapeutics Inc.]

Press Release

FEATURED EVENT

Immune Regulation News Volume 15.31 | Aug 18 2023

CTLA-4 Blockade Induces CD4⁺ T Cell IFNγ-Driven Microglial Phagocytosis and Anti-Tumor Function in Glioblastoma

Lymph Node Sharing between Pancreas, Gut, and Liver Leads to Immune Crosstalk and Regulation of Pancreatic Autoimmunity

Symbiotic Firmicutes Establish Mutualism with the Host via Innate Tolerance and Resistance to Control Systemic Immunity

Short-Term Dietary Changes Can Result in Mucosal and Systemic Immune Depression

CCR2 Macrophage Response Determines the Functional Outcome following Cardiomyocyte Transplantation

Interferon-G-Dependent Interactions between Tissue-Intrinsic γδ T Cells and Tissue-Infiltrating CD8 T Cells Limit Acute Contact Dermatitis

MARCH5-Dependent NLRP3 Ubiquitination Is Required for Mitochondrial NLRP3-NEK7 Complex Formation and NLRP3 Inflammasome Activation

A Target-Based Discovery from a Parasitic Helminth as a Novel Therapeutic Approach for Autoimmune Diseases

SOCS3 Deletion in Effector T Cells Confers an Anti-Tumorigenic Role of IL-6 to the Pro-Tumorigenic Cytokine

Food Allergen Sensitization on a Chip: The Gut–Immune–Skin Axis

Artiva Biotherapeutics Announces FDA Clearance of IND for AlloNK^® Cell Therapy Candidate in Combination with Rituximab in Lupus Nephritis

The Human Microbiome

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Postdoctoral Fellow – Autoimmunity and Transplantation

Postdoctoral Position – Engineering of iPSC-NK cells

Postdoctoral Position – Modeling of the Tumor Microenvironment

Assistant Professor – Immunology

Assistant/Associate Professor – Immunology of Pancreatic Disorders

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