Immune Regulation News Volume 15.33 | Sep 1 2023

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    Laurisa Dohm
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    2023-09-01 | IRN 15.33


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.33 – 1 September, 2023
    TOP STORY

    Metabolic Programs of T Cell Tissue Residency Empower Tumor Immunity

    To systematically define the basis for the metabolic reprogramming supporting TRM cell differentiation, survival and function, investigators leveraged in vivo functional genomics, untargeted metabolomics and transcriptomics of virus-specific memory CD8+ T cell populations.
    [Nature]

    AbstractPress Release
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    Outer Membrane Vesicle-Based Nanohybrids Target Tumor-Associated Macrophages to Enhance Trained Immunity-Related Vaccine-Generated Antitumor Activity

    The authors found that the trained immunity-related vaccine-mediated antitumor mechanism in MC38 tumor model was trained immunity and activated T cell response, whereas in B16-F10 tumor model it was primarily mediated by trained immunity.
    [Advanced Materials]

    Abstract

    Shortwave-Infrared-Light-Emitting Probes for the In Vivo Tracking of Cancer Vaccines and the Elicited Immune Responses

    Researchers reported a cancer vaccine consisting of polymer-coated NaErF4/NaYF4 core–shell down-conversion nanoparticles emitting luminescence in the near-infrared spectral window IIb and with surface-conjugated antigen and electrostatically complexed adjuvant.
    [Nature Biomedical Engineering]

    Full Article

    Tumor-Specific Cholinergic CD4+ T Lymphocytes Guide Immunosurveillance of Hepatocellular Carcinoma

    In a mouse multihit model of hepatocellular carcinoma, investigators observed activation of the adaptive immune response and induction of two populations of CD4+ T cells expressing choline acetyltransferase, including regulatory T cells and dysfunctional PD-1+ T cells.
    [Nature Cancer]

    Full Article

    SEL1L Preserves CD8+ T-Cell Survival and Homeostasis by Fine-Tuning PERK Signaling and the IL-15 Receptor-Mediated mTORC1 Axis

    The authors found that SEL1L deficiency led to a greatly reduced frequency and number of mature T cells, which was further validated by adoptive transfer experiments or bone marrow chimera experiments, accompanied by the induction of multiple forms of cell death.
    [Cellular & Molecular Immunology]

    Abstract

    TREM1 Activation of Myeloid Cells Promotes Antitumor Immunity

    An antibody against mouse triggering receptor expressed on myeloid cells-1 (TREM1), PY159m, promoted antitumor efficacy in syngeneic mouse tumor models.
    [Science Translational Medicine]

    Abstract

    CD45 Alleviates Airway Inflammation and Lung Fibrosis by Limiting Expansion and Activation of ILC2s

    Researchers found that CD45, a membrane-bound tyrosine phosphatase essential for T cell development, negatively regulated group 2 innate lymphoid cells (ILC2s) in a cell-intrinsic manner.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    S100A8/A9-Alarmin Promotes Local Myeloid-Derived Suppressor Cell Activation Restricting Severe Autoimmune Arthritis

    Treatment of myeloid precursors with S100-alarmins during differentiation induced myeloid-derived suppressor cells in a Toll-like receptor 4-dependent manner.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Molecular, Metabolic, and Functional CD4 T Cell Paralysis in the Lymph Node Impedes Tumor Control

    Scientists demonstrated that CD4 tumor-specific T (TTS) cells were quickly primed and began to divide following tumor initiation. However, unlike CD8 TTS cells or exhaustion programming, CD4 TTS cell proliferation was rapidly frozen in place by a functional interplay of regulatory T cells and CTLA4.
    [Cell Reports]

    Full ArticleGraphical Abstract
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    REVIEWS

    Central Regulation of Stress-Evoked Peripheral Immune Responses

    The authors review the specific brain and spinal regions, and the neuronal populations within them, that respond to stress and transmit signals to peripheral tissues via the autonomic nervous system or neuroendocrine pathways to influence immunological function.
    [Nature Reviews Neuroscience]

    Abstract

    Drug Conjugates for Targeting Regulatory T Cells in the Tumor Microenvironment: Guided Missiles for Cancer Treatment

    Scientists discuss key themes and recent advances in drug conjugates targeting Tregs in the tumor microenvironment, as well as future design strategies for successful use of drug conjugates for Treg targeting in immunotherapy.
    [Experimental & Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Activist Investors Once Again Take AIM at Biotech Working on Treatment for Long COVID Symptoms

    Shareholder activists contend that AIM Immunotech has failed to invest enough money into developing its lead asset ampligen.
    [Fierce Biotech]

    Editorial

    US Extends Science Pact with China: What It Means for Research

    The US government has extended for six months a key symbolic agreement to cooperate with China in science and technology.
    [Nature]

    Editorial
    FEATURED EVENT

    AACR Special Conference: Tumor Immunology and Immunotherapy

    October 1 – 4, 2023
    Toronto, Ontario, Canada

    > See All Events

    JOB OPPORTUNITIES

    Associate Research Scientist – Antibody Discovery

    Sanders Tri-Institutional Therapeutics Discovery Institute – New York, New York, United States

    Faculty Positions – Immunology & Microbiology

    The Scripps Research Institute – La Jolla, California, United States

    Professorship – Immune Cell & Tissue Interactions

    University of Regensberg – Heidelberg, Germany

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Assistant/Associate Professor – Immunology of Pancreatic Disorders

    Stanford University – Stanford, California, United States

    > See All Jobs

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