 | | Vol. 15.35 – 15 September, 2023 |
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| Scientists conducted a genome-wide in vivo CRISPR screen in a rat multiple sclerosis model and identified five essential brakes and 18 essential facilitators of T cell migration to the central nervous system.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed by a newly generated B cell-specific Hells conditional knockout mouse model that HELLS (Helicase, Lymphoid Specific) played a pivotal role in T-dependent B cell responses.
[Nature Communications] |
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| Using unique tetramers, scientists traced natural autoreactive B cells specific for a defined triple-helical epitope on collagen type-II, constituting a sizeable fraction of the physiological B cell repertoire in mice, rats, and humans.
[Journal Of Experimental Medicine] |
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| Loss of the guanine nucleotide exchange factor Rin-like led to an increase of Tfh in aging, upon in vivo immunization and acute LCMV Armstrong infection in mice, and in human CD4+ T cell in vitro cultures.
[Journal Of Experimental Medicine] |
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| Nine subsets of 89,542 immune cells with unique properties were identified, of which Cxcl2+ macrophages within the monocyte/macrophage subset were preferentially enriched in the aged liver.
[Hepatology] |
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| Researchers developed a general mathematical framework for the data-driven analysis of collective immune cell dynamics.
[Science Advances] |
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| Using two independent transgenic mouse arthritis models, either TNF- or IL-1β dependent, investigators demonstrated that arthritis developed independently of the microbiota and intestinal inflammation.
[EMBO Molecular Medicine] |
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| Scientists showed that, after coculture with target cells coated with anti-CD20 or anti-CD38, slan+ monocytes mediated trogocytosis, a cell–cell contact dependent, antibody-mediated process that triggers an active, mechanic disruption of target cell membranes.
[Cancer Immunology Research] |
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| In dedicated experimental models of allogeneic hematopoietic stem cell transplantation, researchers evaluated side-by-side the therapeutic effect of two IL-2/anti-IL-2 complexes designed either to boost Tregs, or alternatively to activate effector T cells Teffs, on GVHD occurrence and tumor relapse.
[Haematologica] |
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| The authors review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.
[Cell] |
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| Scientists focus on novel stromal interaction molecule (STIM)-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function.
[Trends In Biochemical Sciences] |
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| Retraction Watch, the influential website and database that tracks retractions in scholarly literature, is joining forces with another publishing nonprofit, Crossref, in hopes of helping researchers and journals flag articles that have been retracted and sustain the literature’s veracity.
[ScienceInsider] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | McGill University – Montreal, Quebec, Canada |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Bethesda, Maryland, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Sanders Tri-Institutional Therapeutics Discovery Institute – New York, New York, United States |
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| | Institut Pasteur – Paris, France |
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