 | | Vol. 15.36 – 22 September, 2023 |
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| The authors showed a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β1-adrenergic receptor ADRB1.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that proliferating effector CD8+ T cells reductively carboxylated glutamine through the mitochondrial enzyme isocitrate dehydrogenase 2.
[Nature] |
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| Scientists exploited tumor microenvironment-responsive nanoparticles that simultaneously harnessed STING and Toll-like receptor 4 (TLR4) to augment STING activation via TLR4-mediated nuclear factor-kappa B signaling pathway stimulation.
[Advanced Materials] |
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| The authors identified a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow of mice and humans that experienced dieting-induced weight loss.
[Cell Metabolism] |
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| Researchers identified 10 subsets of human tumor-infiltrating-Treg, most of which had high concordance with murine tumor-infiltrating-Treg subsets.
[Science Immunology] |
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| Scientists identified a distinct subset of T cell factor-1 (TCF1)+ CD8+ T cells in mouse allogeneic and xenogeneic transplant models of acute graft-versus-host disease.
[Nature Communications] |
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| The prophylactic use of a protein arginine methyltransferase 1 (PRMT1) inhibitor significantly prevented chronic graft-versus-host disease in mice by reducing the percentage of Th17 cells, germinal center B cells, and plasma cells.
[Molecular Therapy] |
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| Investigators established that CD4+ T cells responded to intermittent T cell receptor (TCR) stimulation more efficiently than their CD8+ T cells counterparts and provided evidence that distinct sequences of TCR stimulation encoded different cytokine programs.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Using cell-specific IL-15-deficient mice, researchers showed that hematopoietic cells, but not stromal cells, supported natural killer (NK) cell development in the bone marrow through IL-15.
[Cell Reports] |
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| Scientists review the studies that support or challenge a widely-held view of immune aging, and discuss the implications for vaccination strategies.
[Seminars In Immunology] |
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| Penn Medicine’s Carl June has been named a winner of the 2024 Breakthrough Prize in Life Sciences for the development of CAR T cell immunotherapy, a revolutionary cancer treatment approach in which each patient’s T cells are modified to target and kill their cancer cells.
[Penn Today] |
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| The US biomedical agency tweaked its new policy after an outcry from researchers, but will forge ahead.
[Nature News] |
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| October 17 – 19, 2023
London, England, United Kingdom |
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| | Stanford University – Stanford, California, United States |
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| | Georgetown University – Washington D.C., United States |
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| | McGill University – Montreal, Quebec, Canada |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) – Bethesda, Maryland, United States |
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| | Sanders Tri-Institutional Therapeutics Discovery Institute – New York, New York, United States |
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