Immune Regulation News Volume 15.37 | Sep 29 2023

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    Laurisa Dohm
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    2023-09-29 | IRN 15.37


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.37 – 29 September, 2023
    TOP STORY

    Immunosuppressive CD29+ Treg Accumulation in the Liver in Mice on Checkpoint Inhibitor Therapy

    Flow cytometry and single-cell RNA sequencing were used to characterize hepatic Tregs before and after immune checkpoint inhibitor therapy.
    [Gut]

    Abstract
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    Myo9b Mutations Are Associated with Altered Dendritic Cell Functions and Increased Susceptibility to Autoimmune Diabetes Onset

    Scientists showed that dendritic cells in ALR mice had impaired migratory and T cell priming capability. Genomic comparative analysis maps a 33-bp deletion in the ALR Myosin IXb (Myo9b) gene when compared with NOD genome.
    [Nature Communications]

    Full Article

    A Robust Deep Learning Workflow to Predict CD8+ T Cell Epitopes

    The authors developed TRAP, T cell recognition potential of HLA-I presented peptides, a robust deep learning workflow for predicting CD8  T cell epitopes from MHC-I presented pathogenic and self-peptides.
    [Genome Medicine]

    Full Article

    Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues

    The delivered interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor markedly abated inflammation and dramatically suppressed paw edema, mitigated colitis symptoms, and reduced proinflammatory cytokine levels in the affected tissues.
    [Small]

    Abstract

    A Tryptophan Metabolite Made by a Gut Microbiome Eukaryote Induces Pro-Inflammatory T Cells

    Experiments shone a new light on the ability of the protist microbiome and tryptophan metabolites, derived from them or other sources, to modulate the adaptive immune compartment, particularly in the context of gut inflammatory disorders.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Externalized Histones Fuel Pulmonary Fibrosis via a Platelet-Macrophage Circuit of TGFβ1 and Il-27

    Histones activated platelets to release TGFβ1, which signaled through the TGFbRI/TGFbRII receptor complex on LysM+ cells to antagonize macrophage-derived IL-27 production.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    AbstractPress Release

    Divergent Roles for STAT4 in Shaping Differentiation of Cytotoxic ILC1 and Nk Cells during Gut Inflammation

    By combining genetic and transcriptomic approaches, scientists uncovered divergent roles for STAT4 in regulating effector differentiation of these two functionally related cell types.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Low Dietary Fiber Intake Impairs Small Intestinal Th17 and Intraepithelial T Cell Development Over Generations

    Researchers restored T cell development with dietary fiber supplementation, but this defect became persistent over generations with constant low-fiber diets.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Alterations of Milk Oligosaccharides in Mothers with Gestational Diabetes Mellitus Impede Colonization of Beneficial Bacteria and Development of RORγt+ Treg Cell-Mediated Immune Tolerance in Neonates

    Experiments in gestational diabetes mellitus (GDM) mouse models indicated that decreased contents of milk oligosaccharides in GDM maternal mice reduced colonization of bacteria in the neonatal gut, which impeded development of RORγt+ Treg cell-mediated immune tolerance.
    [Gut Microbes]

    Full ArticleGraphical Abstract
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    REVIEWS

    Membrane Organization by Tetraspanins and Galectins Shapes Lymphocyte Function

    Scientists advocate for a novel approach to study lymphocyte function by globally analysing the role of membrane organizers in the assembly of different membrane complexes, and discuss opportunities to develop therapeutic approaches that act via the modulation of membrane organization.
    [Nature Reviews Immunology]

    Abstract

    Versatile Roles of Innate Lymphoid Cells at the Mucosal Barrier: From Homeostasis to Pathological Inflammation

    The authors discuss recent advances regarding our understanding of the biology of innate lymphoid cells in mucosal tissue health and disease.
    [Experimental & Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    AbbVie Axes Caribou CAR-T Deal, Continuing Cascade of Punted Cancer Pacts

    AbbVie has decided it can do without Caribou Biosciences. The Big Pharma is terminating its off-the-shelf CAR-T pact with the biotech, depriving Caribou of the chance to pocket up to $350 million in milestones per program.
    [Fierce Biotech]

    Editorial
    FEATURED EVENT

    Tissue, Matrix, and Pathobiology: Joint Meeting of ASMB, HCS, and ASIP

    October 22 – 25, 2023
    Salt Lake City, Utah, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Immunology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Scientific Director – Intramural Research Program

    National Cancer Institute – Bethesda, Maryland, United States

    Research Associate – Tissue Immunology

    Imperial College London – London, England, United Kingdom

    Postdoctoral Position – Mucosal Immunity

    Stanford University – Stanford, California, United States

    Assistant/Associate/Full Professor – Director of Allergy and Immunology Division

    McGill University – Montreal, Quebec, Canada

    > See All Jobs

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