Immune Regulation News Volume 15.38 | Oct 6 2023

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    Laurisa Dohm
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    2023-10-06 | IRN 15.38


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.38 – 6 October, 2023
    TOP STORY

    The PTPN2/PTPN1 Inhibitor ABBV-CLS-484 Unleashes Potent Anti-Tumor Immunity

    The authors showed that AC484 inflamed the tumor microenvironment and promoted natural killer cell and CD8+ T cell function by enhancing JAK–STAT signalling and reducing T cell dysfunction.
    [Nature]

    Full ArticlePress Release
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    NKG2D-Mediated Detection of Metabolically Stressed Hepatocytes by Innate-Like T Cells Is Essential for Initiation of NASH and Fibrosis

    Tissue-resident innate-like T cells, most notably γδ T cells, were activated through NKG2D and secreted IL-17A. IL-17A licensed hepatocytes to produce chemokines that recruited proinflammatory cells into the liver, which caused nonalcoholic steatohepatitis and fibrosis.
    [Science Immunology]

    Abstract

    Laboratory Mice with a Wild Microbiota Generate Strong Allergic Immune Responses

    To uncover the impact of lifelong microbial exposure on the development of allergic inflammation, researchers compared experimental wildling mice, which have a representative breadth of naturally occurring pathogens, to specific pathogen–free mice.
    [Science Immunology]

    Abstract

    USP47 Inhibits m6A-Dependent C-Myc Translation to Maintain Regulatory T Cell Metabolic and Functional Homeostasis

    USP47 ablation compromised Treg cell homeostasis and function in vivo, resulting in the development of inflammatory disorders, and boosted antitumor immune responses.
    [Journal Of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    TLR9 Ligand Sequestration by Chemokine CXCL4 Negatively Affects Central B Cell Tolerance

    The authors showed that CXCL4, a chemokine involved in systemic sclerosis, abrogated TLR9 function in B cells by sequestering TLR9 ligands away from the endosomal compartments where this receptor resided.
    [Journal Of Experimental Medicine]

    Abstract

    High NEK2 Expression in Myeloid Progenitors Suppresses T Cell Immunity in Multiple Myeloma

    Investigators found that loss of Never in mitosis gene A-related kinase 2 (NEK2) in tumor microenvironmental cells was associated with multiple myeloma growth suppression.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Intratumoral Co-Injection of NK Cells and NKG2A-Neutralizing Monoclonal Antibodies

    Scientists found that intratumoral delivery of NK cells attained significant therapeutic effects only if co-injected with anti-NKG2A and anti-Qa-1b blocking monoclonal antibodies against solid mouse tumor models.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Single-Cell Profiling and Zebrafish Avatars Reveal LGALS1 As Immunomodulating Target in Glioblastoma

    Differential gene expression analysis, immunohistochemistry on original tumor samples, and knock-out experiments in zebrafish identified LGALS1 as a primary regulator of immunosuppression.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Effector Memory T Cells Induce Innate Inflammation by Triggering DNA Damage and a Non-Canonical STING Pathway in Dendritic Cells

    Researchers reported the surprising discovery that T effector memory cells triggered double-strand DNA breaks via mitochondrial reactive oxygen species production in interacting dendritic cells.
    [Cell Reports]

    AbstractFull ArticleGraphical Abstract
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    REVIEWS

    Regulatory T Cells in Dominant Immunological Tolerance

    The authors focus on the myriad roles played by Treg cells in immune tolerance and host homeostasis and the potential to harness these cells in novel therapeutic approaches to human diseases.
    [Journal Of Allergy And Clinical Immunology]

    Abstract

    Carbon Metabolism in the Regulation of Macrophage Functions

    Scientists summarize the current understanding of the crosstalk between carbon metabolism and epigenetic modifications in macrophages under physiological conditions and in the tumor microenvironment, and provide targets and further directions for macrophage-associated diseases.
    [Trends In Endocrinology And Metabolism]

    Full Article
    INDUSTRY AND POLICY NEWS

    AI Beats Human Sleuth at Finding Problematic Images in Research Papers

    An algorithm that takes just seconds to scan a paper for duplicated images racks up more suspicious images than a person.
    [Nature News]

    Editorial
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