Immune Regulation News Volume 15.39 | Oct 13 2023

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    Laurisa Dohm
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    2023-10-13 | IRN 15.39


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.39 – 13 October, 2023
    TOP STORY

    Targeting PGLYRP1 Promotes Antitumor Immunity while Inhibiting Autoimmune Neuroinflammation

    Genetic deletion of Pglyrp1 in mice led to decreased tumor growth and an increased activation/effector phenotype in CD8+ T cells, suggesting an inhibitory function of peptidoglycan recognition protein 1 (PGLYRP1) in CD8+ T cells.
    [Nature Immunology]

    Abstract
    View tips on how to organize your lab notebooks, references and protocols.
    PUBLICATIONSRanked by the impact factor of the journal

    Card9/Neutrophil Signaling Axis Promotes IL-17A-Mediated Ankylosing Spondylitis

    Experiments in SKG, Card9−/−SKG, neutrophil-deplete SKG mice along with in vitro murine, neutrophil and CD4+ T cell cocultures examined Card9 function in neutrophil activation, Th17 induction and arthritis in experimental ankylosing spondylitis.
    [Annals Of The Rheumatic Diseases]

    Full ArticlePress Release

    Systematic Identification of Gene Combinations to Target in Innate Immune Cells to Enhance T Cell Activation

    Researchers conducted high multiplicity of perturbations and cellular Indexing of transcriptomes and epitopes to find combinations of genes whose joint targeting improved antigen-presenting cell activity and enhanced their ability to activate T cells.
    [Nature Communications]

    Full Article

    Regulatory T Cells Control Staphylococcus aureus and Disease Severity of Cutaneous Leishmaniasis

    The authors reported that depletion of Foxp3+ Tregs in Staphylococcus aureus–colonized mice resulted in less IL-17 and an IFN-γ–dependent skin inflammation with impaired S. aureus immunity.
    [Journal Of Experimental Medicine]

    Abstract

    Lipid Accumulation-Mediated Histone Hypoacetylation Drives Persistent NK Cell Dysfunction in Anti-Tumor Immunity

    Scientists showed that NK cells isolated from high-fat-diet mice or treated with oleic acid in vitro exhibited sustainable functional defects, even after removal from hyperlipidemic milieu.
    [Cell Reports]

    Full ArticleGraphical Abstract

    RORγt+ C-Maf+ Vγ4+ γδ T Cells Are Generated in the Adult Thymus but Do Not Reach the Periphery

    Investigators used a mouse model in which T cells were generated exclusively in the adult thymus and employed single-cell chromatin state analysis to study their development.
    [Cell Reports]

    Full ArticleGraphical Abstract

    TRIM55 Promotes Noncanonical NF-κB Signaling and B Cell–Mediated Immune Responses by Coordinating p100 Ubiquitination and Processing

    The ubiquitination-dependent processing of p100 is a critical step in the activation of the noncanonical NF-κB pathway. Scientists investigated the molecular mechanisms regulating this process and showed that TRIM55 was the E3 ubiquitin ligase that mediated the ubiquitination of p100 and coordinated its processing.
    [Science Signaling]

    Full Article

    AIM2 Promotes TH17 Cells Differentiation by Regulating RORγt Transcription Activity

    AIM2 is located in the nucleus of Th17 cells, where it interacted with RORγt, enhancing its binding to the Il17a promoter. The absence of AIM2 hindered naive CD4 T cells from differentiating into functional Th17 cells and from inducing colitis in Rag1-/- mice.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Development of Protein–Polymer Conjugate Nanoparticles for Modulation of Dendritic Cell Phenotype and Antigen-Specific CD4 T Cell Responses

    To study the relationship between polymeric nanoparticles design parameters and the modulation of innate and antigen-specific adaptive immune cell responses, researchers developed ovalbumin protein-poly(lactic-co-glycolic acid) bioconjugate polymeric nanoparticles.
    [ACS Applied Polymer Materials]

    AbstractGraphical Abstract
    SepMateâ„¢ PBMC Isolation
    REVIEWS

    Cardinal Features of Immune Memory in Innate Lymphocytes

    It is now appreciated that innate lymphocytes possess memory properties akin to those of adaptive immune cells.The authors draw parallels from T cell biology to explore the key features of immune memory in innate lymphocytes, including quantity, quality, and location.
    [Nature Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Kyverna Therapeutics Announces FDA Clearance of IND for KYV-101, a Novel Fully Human CD19 CAR T-Cell Therapy to Treat Scleroderma

    This is the third IND clearance for KYV-101, a novel, fully human CD19 CAR T-cell therapy designed for use in patients with B cell-driven autoimmune diseases.
    [Kyverna Therapeutics]

    Press Release
    FEATURED EVENT

    Bioengineering for Global Health

    November 11 – 15, 2023
    Nashville, Tennessee, United States

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Cancer Immunotherapy Research

    University of Turku – Turku, Finland

    Assistant Professor – Immunology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Scientific Director – Intramural Research Program

    National Cancer Institute – Bethesda, Maryland, United States

    Research Associate – Tissue Immunology

    Imperial College London – London, England, United Kingdom

    Assistant/Associate/Full Professor – Director of Allergy and Immunology Division

    McGill University – Montreal, Quebec, Canada

    > See All Jobs

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