Immune Regulation News Volume 15.41 | Oct 27 2023

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    Laurisa Dohm
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    2023-10-27 | IRN 15.41


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.41 – 27 October, 2023
    TOP STORY

    Ceria-Vesicle Nanohybrid Therapeutic for Modulation of Innate and Adaptive Immunity in a Collagen-Induced Arthritis Model

    Scientists developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to address multiple factors in rheumatoid arthritis.
    [Nature Nanotechnology]

    AbstractPress Release
    PUBLICATIONSRanked by the impact factor of the journal

    Control of CD4+ T Cells to Restrain Inflammatory Diseases via Eukaryotic Elongation Factor 2 Kinase

    Investigators uncovered that the deficiency of eukaryotic elongation factor 2 kinase disrupted the survival and proliferation of CD4+ T cells, and impaired their ability to secrete cytokines.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Resident Regulatory T Cells Reflect the Immune History of Individual Lymph Nodes

    Scientists used in situ labeling with a stabilized photoconvertible protein to uncover turnover rates of Treg in lymph nodes in vivo.
    [Science Immunology]

    Abstract

    Tissue-infiltrating Alloreactive T Cells Require Id3 to Deflect PD-1-Mediated Immune Suppression during GVHD

    The authors demonstrated here that Id3, a DNA-binding inhibitor, was critical for sustaining T cell responses in GVHD target tissues in mice, including the liver and intestine.
    [Blood]

    Abstract

    The Transcription Factor Zeb1 Controls Homeostasis and Function of Type 1 Conventional Dendritic Cells

    Type 1 conventional dendritic cells from sources of Zeb1-deficient mice displayed impaired cross-presentation of exogenous antigens, compromising antitumor CD8+ T cell responses.
    [Nature Communications]

    Full Article

    Immune Synapse Formation Promotes Lipid Peroxidation and MHC-I Upregulation in Licensed Dendritic Cells for Efficient Priming of CD8+ T Cells

    Researchers described that antigen presentation induced an upregulation of MHC-I protein molecules and increased lipid peroxidation on post-synaptic dendritic cells in vitro and in vivo.
    [Nature Communications]

    Full Article

    MHC Class Ib–Restricted CD8+ T Cells Possess Strong Tumoricidal Activities

    Investigators showed that CX3CR1-expressing Ib-CD8+ T cells highly expressed cytotoxic factors, austerely resisted exhaustion, and effectively eliminated various tumors.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    CD226 Maintains Regulatory T Cell Phenotype Stability and Metabolism by the mTOR/Myc Pathway under Inflammatory Conditions

    Conditional deletion of CD226 within Foxp3+ cells exacerbated symptoms in murine GVHD models, and Treg cell-specific deletion of CD226 increased the Treg cell percentage in immune organs but weakened their immunosuppressive function with a T helper 1-like phenotype conversion under inflammation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Quantitative Analyses of T Cell Motion in Tissue Reveals Factors Driving T Cell Search in Tissues

    To better understand how different tissue environments might affect T cell motility, scientists compared multiple features of T cell motion including speed, persistence, turning angle, directionality, and confinement of motion from T cells moving in multiple tissues using tracks collected with microscopy from murine tissues.
    [eLife]

    Full Article
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Macrophage and T Cell Networks in Adipose Tissue

    The authors provide a state-of-the-art understanding of adipose tissue macrophages and T cells and discuss how their unique niche can help us to better understand diversity in leukocyte responses.
    [Nature Reviews Endocrinology]

    Abstract

    Regulatory T Cells in Allergic Inflammation

    Interruption of Treg cell subversion in chronic allergic inflammatory conditions may provide novel therapeutic strategies by re-establishing effective immune regulation.
    [Seminars in Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    First Detailed US Scientific Integrity Draft Policies Get Mixed Responses

    Keep working on it. That’s the reaction of US science watchdog groups to the first attempts by federal health agencies to flesh out a promise by President Joe Biden to restore trust in government by ensuring that government scientists are free to do their jobs without political meddling.
    [ScienceInsider]

    Editorial

    NKGen Biotech Announces FDA Clearance of Investigational New Drug Application for SNK01 NK Cell Therapy to Treat Alzheimer’s Disease

    SNK01 is an autologous, non-genetically modified natural killer (NK) cell product that has enhanced cytotoxicity and activating receptor expression. This approved trial of 30 patients with moderate Alzheimer’s Disease will look to commence before the end of this year.
    [NKGen Biotech Inc.]

    Press Release
    FEATURED EVENT

    9th International Conference on Infectious Disease Dynamics

    November 28 – December 1, 2023
    Bologna, Italy

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Immunology & Microbiology

    Westlake University – Hangzhou, Zhejiang, China

    Postdoctoral Associate – Immune Cells in Blood Diseases and GvHD

    Baylor College of Medicine – Houston, Texas, United States

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Assistant Professor – Immunology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Researcher – Cancer Immunology and Immunotherapy

    University of Turku – Turku, Finland

    > See All Jobs

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