Immune Regulation News Volume 15.42 | Nov 3 2023

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    Laurisa Dohm
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    2023-11-03 | IRN 15.42


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.42 – 3 November, 2023
    TOP STORY

    CD8 T Cell Tolerance Results from Eviction of Immature Autoreactive Cells from the Thymus

    The authors reported that in mice, CD8 T cell tolerance resulted from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiated into self-tolerant mature CD8 T cells.
    [Science]

    Abstract
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    Ikaros Is a Principal Regulator of Aire+ mTEC Homeostasis, Thymic Mimetic Cell Diversity, and Central Tolerance

    Thymic epithelial cell (TEC)-specific deletion of Ikzf1 in mice resulted in a profound decrease in Aire+ medullary TECs, a global loss of tissue-specific antigengene expression, and the development of autoimmunity.
    [Science Immunology]

    Abstract

    BCL6 Promotes a Stem-Like CD8+ T Cell Program in Cancer via Antagonizing BLIMP1

    Investigators showed that Bcl6 deficiency reduced the persistence of intratumor stem/progenitor-like CD8+ T cell cells, without affecting their generation, thus abrogating long-term tumor control.
    [Science Immunology]

    Abstract

    Continually Recruited Naïve T Cells Contribute to the Follicular Helper and Regulatory T Cell Pools in Germinal Centers

    Scientists showed that derminal center reactions continually recruited T cells from both the naïve conventional and naive thymic Treg repertoires.
    [Nature Communications]

    Full Article

    An In Situ Dual-Anchoring Strategy for Enhanced Immobilization of PD-L1 to Treat Autoimmune Diseases

    Researchers reported a two-step dual-anchor coupling strategy for enhanced immobilization of PD-L1 on target endogenous cells by integrating bioorthogonal chemistry and physical insertion of the cell membrane.
    [Nature Communications]

    Full Article

    STIM-Mediated Calcium Influx Regulates Maintenance and Selection of Germinal Center B Cells

    The authors showed that stromal interacting molecule (STIM)-deficient B cells had reduced B cell competitiveness compared with wild-type B cells during germinal center responses.
    [Journal Of Experimental Medicine]

    Full Article
    Graphical
    Abstract

    Group 3 Innate Lymphoid Cells Exacerbate Lupus Nephritis by Promoting B Cell Activation in Kidney Ectopic Lymphoid Structures

    Using MRL/lpr lupus mice and a nephrotoxic serum-induced lupus nephritis model, investigators demonstrated that group 3 innate lymphoid cells accumulated in the kidney migrated predominantly from the intestine.
    [Advanced Science]

    Full Article

    DOK3 Promotes Atopic Dermatitis by Enabling the Phosphatase PP4C to Inhibit the T Cell Signaling Mediator CARD11

    Knocking out Dok3 enhanced the production of the cytokine IFN-γ by T cells, which conferred protection against experimental atopic dermatitis–like skin inflammation in mice.
    [Science Signaling]

    Abstract

    B Cell Mediated CD4 T Cell Co-Stimulation via CD86 Exacerbates Pro-Inflammatory Cytokine Production during Autoimmune Intestinal Inflammation

    Depleting B cells through anti-CD20 antibody treatment or blocking co-stimulatory signals mediated by CD86 through CTLA-4-Ig diminished intestinal inflammation in a mouse model of chronic inflammatory-bowel disease at the onset of disease.
    [Mucosal Immunology]

    Abstract
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    REVIEWS

    CD8 T Cell Subsets: Heterogeneity, Functions, and Therapeutic Potential

    The authors highlight recent advancements in the understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies.
    [Experimental & Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Celltrion USA Announces FDA Approval of ZYMFENTRA® for the Treatment of People with Inflammatory Bowel Disease

    ZYMFENTRA® for maintenance therapy in adults with moderately to severely active ulcerative colitis and Crohn’s disease following treatment with an infliximab product administered intravenously.
    [BioSpace (Celltrion USA)]

    Press Release
    FEATURED EVENT

    ESMO Immuno-Oncology Congress 2023

    December 6 – 8, 2023
    Geneva, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Immunity & Immunotherapies

    Seattle Children’s Research Institute – Seattle, Washington, United States

    Postdoctoral Associate – Immune Cells in Blood Diseases and GvHD

    Baylor College of Medicine – Houston, Texas, United States

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Researcher – Cancer Immunology and Immunotherapy

    University of Turku – Turku, Finland

    Postdoctoral Scholar – Innate Immunity in the Pathogenesis of Inflammatory Intestinal Diseases

    University of Calgary – St Albert, Alberta, Canada

    > See All Jobs

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