Immune Regulation News Volume 15.43 | Nov 10 2023

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    Noshin Noorjahan
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    2023-11-10 | IRN 15.43


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.43 – 10 November, 2023
    TOP STORY

    PD-1 Signaling Negatively Regulates the Common Cytokine Receptor γ Chain via MARCH5-Mediated Ubiquitination and Degradation to Suppress Anti-Tumor Immunity

    Scientists showed that PD-1 ligation resulted in BATF-dependent transcriptional induction of the membrane-associated E3 ubiquitin ligase MARCH5.
    [Cell Research]

    Full Article
    PUBLICATIONSRanked by the impact factor of the journal

    Selective IL-27 Production by Intestinal Regulatory T Cells Permits Gut-Specific Regulation of TH17 Cell Immunity

    Researchers showed that IL-27 was specifically produced by intestinal Treg cells to regulate helper T17 cell (TH17 cell) immunity.
    [Nature Immunology]

    Abstract

    Distinct Use of Super-Enhancer Elements Controls Cell Type–Specific CD25 Transcription and Function

    The authors investigated CD25 regulation and function using a series of mice with deletions spanning STAT5-binding elements.
    [Science Immunology]

    Abstract

    The OX40-TRAF6 Axis Promotes CTLA-4 Degradation to Augment Antitumor CD8+ T Cell Immunity

    By using TNF receptor-associated factor 6 (TRAF6)-deficient mice and retroviral overexpression experiments, researchers demonstrated that TRAF6 promoted cytotoxic T-lymphocyte associated protein 4 (CTLA-4) degradation in a T cell-intrinsic manner, which was dependent on the RING domain of TRAF6.
    [Cellular & Molecular Immunology]

    Abstract

    IL-21R-STAT3 Signaling Initiates a Differentiation Program in Uterine Tissue-Resident NK Cells to Support Pregnancy

    Investigators characterized uterine tissue-resident Natural Killer cells longitudinally during pregnancy by single cell RNA sequencing and found that the combined expression pattern of 4-1BB and CD55 defined their three distinct stages of differentiation in mice.
    [Nature Communications]

    Full Article

    Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

    By comprehensively mapping 3D chromatin organization during Treg cell differentiation, scientists showed that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression.
    [Nature Communications]

    Full Article

    Target ssDNA Activates the NADase Activity of Prokaryotic SPARTA Immune System

    Researchers used cryo-electron microscopy to determine the structures of inactive monomeric and active tetrameric Crenotalea thermophila short prokaryotic Ago/TIR–APAZ (SPARTA) complexes.
    [Nature Chemical Biology]

    AbstractGraphical Abstract

    RANKL/RANK Is Required for Cytokine-Induced Beta Cell Death; Osteoprotegerin, a RANKL Inhibitor, Reverses Rodent Type 1 Diabetes

    Investigators demonstrated that the receptor activator of nuclear factor kappa Β (NF-κB) (RANK) pathway mediated cytokine-induced rodent and human β cell death through RANK-tumor necrosis factor receptor–associated factor 6 interaction and induction of NF-κB activation.
    [Science Advances]

    Full Article

    EZH2 Inhibition Stimulates Repetitive Element Expression and Viral Mimicry in Resting Splenic B Cells

    Scientists demonstrated that inhibitors of enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, stimulated repeat misexpression and cell death in resting splenic B cells.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Lipin-2 Regulates the Antiviral and Anti-Inflammatory Responses to Interferon

    Researchers revealed that lipin-2, a phosphatidic acid phosphatase whose mutations produce an autoinflammatory syndrome known as Majeed syndrome in humans, was regulated by interferon in a signal transducer and activator of transcription-1-dependent manner.
    [EMBO Reports]

    Full ArticleGraphical Abstract
    Request your free copy of the 'Human Immune Cytokines' Wallchart
    REVIEWS

    Immune Mechanisms of Depression in Rheumatoid Arthritis

    The authors focus on interactions between peripheral and central immunobiological mechanisms in the context of both rheumatoid arthritis and major depressive disorder.
    [Nature Reviews Rheumatology]

    Abstract

    Macrophage Phenotypes and Functions: Resolving Inflammation and Restoring Homeostasis

    Investigators review recent work highlighting the importance of macrophages in tissue resolution and the return to homeostasis.
    [Trends in Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    £17M Awarded to Develop Globally Important Vaccine Hubs

    Imperial researchers will lead two hubs to improve global access to life-saving vaccines. The hubs, led by Professor Robin Shattock and Professor Faith Osier, will develop new vaccine technologies that can be easily and cheaply manufactured in low- and middle-income countries.
    [Imperial College London]

    Press Release
    FEATURED EVENT

    9th International Conference on Infectious Disease Dynamics

    November 28 – December 1, 2023
    Bologna, Italy

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Cancer Bioinformatics and Immunotherapies

    Armenian Bioinformatics Institute – Yerevan, Armenia

    Research Associate – Immunophenotyping of Tumor Microenvironment

    Cedars-Sinai – Los Angeles, California, United States

    Scientist Positions – Pharmaceutical Sciences

    China Pharmaceutical University – Nanjing, Jiangsu, China

    Postdoctoral Position – Human Immunology

    Emory University Lowance Center for Human Immunology – Atlanta, Georgia, United States

    Assistant Professor – Immunity and Immunotherapies

    Seattle Children’s Research Institute – Seattle, Washington, United States

    > See All Jobs

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