Immune Regulation News Volume 15.44 | Nov 17 2023

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    Noshin Noorjahan
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    2023-11-17 | IRN 15.44


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.44 – 17 November, 2023
    TOP STORY

    Single-Cell CRISPR Screens In Vivo Map T Cell Fate Regulomes in Cancer

    Investigators systematically mapped causal gene regulatory networks using single-cell CRISPR screens in vivo and discovered checkpoints for CD8+ cytotoxic T cell differentiation.
    [Nature]

    Full ArticlePress Release
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    PUBLICATIONSRanked by the impact factor of the journal

    Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury

    Prenatal anti-Müllerian hormone treatment or peripubertal letrozole infusion was used to establish mouse models of polycystic ovary syndrome.
    [Circulation]

    Abstract

    Transcriptomes and Metabolism Define Mouse and Human MAIT Cell Populations

    Researchers defined mucosal-associated invariant T (MAIT) cell populations in different organs and characterized the developmental pathway of mouse and human MAIT cells in the thymus using single-cell RNA sequencing and phenotypic and metabolic analyses.
    [Science Immunology]

    AbstractPress Release

    CD97 Negatively Regulates the Innate Immune Response against RNA Viruses by Promoting RNF125-Mediated RIG-I Degradation

    Scientists reported that CD97 inhibited virus-induced type-I interferon release and enhanced RNA virus replication in cells and mice.
    [Cellular & Molecular Immunology]

    Abstract

    Identification of a Small-Molecule Tim-3 Inhibitor to Potentiate T Cell–Mediated Antitumor Immunotherapy in Preclinical Mouse Models

    Using a strategy combining virtual and functional screening, the authors identified a compound named ML-T7 that targeted the FG-CC′ cleft of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3).
    [Science Translational Medicine]

    Abstract

    Themis2 Regulates Natural Killer Cell Memory Function and Formation

    Researchers identified the scaffold protein Themis2 as a critical regulator of memory NK cell differentiation and function.
    [Nature Communications]

    Full Article

    Nanomedicine-Based Co-Delivery of a Calcium Channel Inhibitor and a Small Molecule Targeting CD47 for Lung Cancer Immunotherapy

    Using a layered double hydroxide nanosheet carrier, the authors co-delivered a T-type calcium channel inhibitor and a CD47 inhibitor into lung tumors.
    [Nature Communications]

    Full Article

    A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer

    Investigators performed a metabolic CRISPR/Cas9 screen and pinpointed novel candidate positive and negative metabolic regulators of forkhead box P3.
    [Cancer Immunology Research]

    Abstract

    IL6 Suppresses Vaccine Responses in Neonates by Enhancing IL2 Activity on T Follicular Helper Cells

    The authors found that splenic IL-6 levels rapidly increased in both adult and neonatal mice following immunization, but the increase in neonatal mice was significantly more than that of adult mice.
    [npj Vaccines]

    Full Article
    A webinar on covid-19 and the central nervous system, presented by Eric Song. Click here to listen
    REVIEWS

    Sex Hormone Signaling and Regulation of Immune Function

    The quest to uncover the mechanisms for biological sex differences in the immune system has intensified, with considerable literature pointing toward sex hormonal influences on immune cell function.
    [Immunity]

    Full Article
    INDUSTRY AND POLICY NEWS

    Icahn School of Medicine at Mount Sinai Secures $5 Million NIH Grant for Cutting-Edge Cancer Target Discovery and Development Center

    The Department of Immunology and Immunotherapy and the Icahn Genomics Institute at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant from the National Cancer Institute to establish a state-of-the-art center dedicated to the discovery and development of cancer therapy.
    [Icahn School of Medicine (EurekaAlert)]

    Press Release
    FEATURED EVENT

    2024 Alcohol and the Nervous System Conference GRC

    February 11 – 16, 2024
    Galveston, Texas, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Research Positions – Cancer Research Center

    German Cancer Research Center in the Helmholtz Association – Heideland, Germany

    Scientific Research Personnel – Immunology, Vaccinology & Nanomedicine

    Chinese Academy of Sciences – Shenzhen, China

    Postdoctoral Researcher – Cancer Bioinformatics and Immunotherapies

    Armenian Bioinformatics Institute – Yerevan, Armenia

    Research Associate – Immunophenotyping of Tumor Microenvironment

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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