 | | Vol. 15.45 – 24 November, 2023 |
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| By cotargeting myeloid activation molecules, scientists leveraged the myeloid compartment as a therapeutic vulnerability in mouse models of pancreatic cancer.
[Science Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed positive correlations between serum levels of Ca10, tumor size, and the generation of splenic Tregs in mice bearing solid Ehrlich’s tumor.
[Cellular & Molecular Immunology] |
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| The authors identified, by high-content screening, SEPTIN2 as a negative regulation of interferon-gamma-independent macrophage autoactivation.
[Nature Communications] |
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| Researchers utilized cryo-electron tomography to examine the nuclei of mouse neutrophils, revealing the cytoplasmic enrichment of intermediate filaments on the concave regions of the nuclear envelope.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators described T cell selection, activation, and T cell repertoire diversity in female mice deficient for B lymphocyte–induced maturation protein-1 in dendritic cells. These mice exhibited a lupus-like phenotype with an expanded population of T follicular helper cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists used the Bcl-2 family inhibitor ABT-263 to investigate the effects of pre-vaccination senolysis on immune responses in old mice. Two different ovalbumin-containing vaccines were tested.
[Aging Cell] |
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| By performing RNA sequencing to compare the gene expression profiles between Huntington’s disease (HD) knockin pigs and mice, researchers found that genes related to interleukin-17 (IL-17) signaling were upregulated in the HD pig brains compared to the mouse brains.
[Cell Reports] |
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| Investigators found that T-cell-specific Rip1 KO mice showed age-related T cell changes and exhibited signs of accelerated aging-like phenotypes, including inflammation, multiple age-related diseases, and a shorter lifespan.
[EMBO Reports] |
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| The authors demonstrated that isoaspartyl modifications arise within the ZAP70 protein tyrosine kinase upon T cell antigen receptor engagement. The enzyme protein L-isoaspartate O-methyltransferase evolved to repair isoaspartyl modifications in cells.
[Autoimmunity] |
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| Scientists provide a comprehensive review of immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome with a specific focus on mechanistic findings, and implications for diagnostics and treatments, details of which may be highly relevant to other primary immune regulatory diseases.
[Immunological Reviews] |
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| Another big success for the University of Bonn in securing grants from the European Research Council (ERC), with three researchers receiving an ERC Consolidator Grant: Drs. Jan Hasenauer, Florian I. Schmidt, and Evgeny Shinder.
[University of Bonn] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | Rutgers Health – Newark, New Jersey, United States |
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| | University of Melbourne – Melbourne, Australia |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Chinese Academy of Sciences – Shenzhen, China |
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