 | | Vol. 15.48 – 15 December, 2023 |
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| Investigators characterized how aging induced changes in immunological signatures that inhibited tissue repair and therapeutic response to a clinical regenerative biological scaffold derived from extracellular matrix.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported a lipid nanoparticle-screening method for the optimization of the type of helper lipid and of lipid-component ratios to enhance the delivery of tumor-antigen-encoding mRNA to dendritic cells and their immune-activation profile towards enhanced antitumor activity.
[Nature Biomedical Engineering] |
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| Using single-cell RNA sequencing, researchers found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion, restoring T cell function and promoting a favorable immunotherapy response.
[Cellular & Molecular Immunology] |
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| Investigators described the development of Paneth cell metaplasia in a murine model of chronic myelogenous leukemia that was driven by an inducible bcr-abl oncogene.
[Nature Communications] |
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| Scientists showed that adenosine 5′-triphosphate citrate lyase (ACLY) inhibition up-regulated programmed death ligand 1 immune checkpoint expression in cancer cells and induced T cell dysfunction to drive immunosuppression and compromise its antitumor effect in immunocompetent mice.
[Science Advances] |
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| The authors explored the functional properties of sCTLA-4 and evaluated the efficacy of isoform-specific anti-sCTLA-4 antibody targeting in murine cancer model.
[Molecular Therapy] |
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| Using a mouse model of ovarian cancer, researchers demonstrated the oncolytic effect and immune-modulatory capacities of CARG-2020.
[Cancer Immunology Research] |
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| The authors showed that CD62L and CD44 were progressively expressed on mouse memory B cells and identified transcriptionally and functionally distinct memory B cell subsets.
[Cell Reports] |
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| Scientists showed that B lymphoid tyrosine kinase (BLK) positively regulated TLR/IL-1R–mediated inflammatory response. BLK-deficient mice produced less inflammatory cytokines and were more resistant to death upon IL-1β challenge.
[Journal of Cell Biology] |
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| Investigators summarize the molecular signaling pathways regulating immune responses to pathogen infection in Drosophila, with a focus on ubiquitin-dependent control of innate immunity and inflammatory signaling.
[FEBS Journal] |
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| PICI announced it has added Weill Cornell Medicine to its network of preeminent academic and medical research institutions at the forefront of the fight against cancer.
[Weill Cornell Medicine] |
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| February 11 – 16, 2023
Barga, Italy |
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| | University of Surrey – Surrey, England, United Kingdom |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Institut Necker Enfants Malades – Paris, France |
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| | Institut Pasteur – Paris, France |
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