 | | Vol. 16.02 – 19 January, 2024 |
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| Researchers characterized more than 1,000 autoreactive single T cell clones, which revealed a polyclonal T cell receptor repertoire, short CDR3β lengths, preferential HLA-DR restrictions, and recognition of immunodominant epitopes.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed a bispecific dendritic cell-T cell engager, a reagent that facilitated physical interactions between PD-1+ T cells and conventional type I dendritic cells.
[Cell] |
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| The authors reported that neddylation inactivation with MLN4924, a specific inhibitor of NEDD8-activating enzyme E1, or genetic abrogation of Ube2m in T cells decreased double-negative T cell accumulation and attenuated murine lupus development.
[Signal Transduction And Targeted Therapy] |
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| Investigators overlapped differentially expressed genes with publicly available microarray datasets and performed functional in vitro studies, including an in vitro suppression assay and organoid systems, to model gene expression changes observed in Crohn’s disease Tregs and to test predicted therapeutics.
[Gastroenterology] |
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| Scientists reported that a combination of glutaminase inhibitor CB-839 and 5-FU inhibited the growth of PIK3CA mutant colorectal cancers in xenograft, syngeneic, and genetically engineered mouse models in part through neutrophil extracellular traps.
[Journal Of Clinical Investigation] |
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| Researchers demonstrated that mural cells decreased coverage around blood vessels in the dura, the outermost layer of the meninges, and upregulated gene pathways involved in leukocyte migration in presymptomatic experimental autoimmune encephalomyelitis.
[Journal of Experimental Medicine] |
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| Antigen-specific assay systems revealed that human CD8 T cells not only mediated cytotoxicity but also promoted tissue remodeling.
[Journal Of Experimental Medicine] |
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| Researchers employed single-cell RNA sequencing, single-cell Tra and Trb sequencing, adoptive transfers, photoconvertible mice, cellular interaction analyses, and in vitro cultures to dissect the evolving heterogeneity of epididymal visceral adipose tissue Tregs with aging and obesity.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors found extremely low levels of BTB and CNC homology 2 (BACH2) in T-ALL clinical samples and cell lines compared to normal T cells. Overexpression of BACH2 in T-ALL cells not only induced cell growth retardation but also inhibited cancer progression and infiltration in xenografts.
[Cell Death & Disease] |
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| The registrational clinical trials and registry data of JAK inhibitors did not identify a difference in the risk of major adverse cardiovascular events, venous thromboembolism, malignancies or infections with a JAK inhibitor versus a biologic DMARD.
[Nature Reviews Rheumatology] |
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| Investigators summarize their knowledge of the roles of these NF-κB pathways, which are activated in different intestinal cell types by specific ligands, and their cross-talk, in fueling aberrant intestinal inflammation.
[Science Signaling] |
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| Takeda announced that the FDA approved HYQVIA® for the treatment of chronic inflammatory demyelinating polyneuropathy CIDP as maintenance therapy to prevent the relapse of neuromuscular disability and impairment in adults.
[Takeda] |
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| Calypso Biotech, a European immunotherapy biotech company focused on the research and development of novel biologics, announced it had agreed to be acquired by Novartis. Calypso’s shareholders are set to receive an upfront payment of $250 million and are eligible to receive development milestones of up to $175 million.
[PharmTech.com] |
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| March 11 – 14, 2024
San Diego, California, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Sanofi – Cambridge, Massachusetts, United States |
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| | University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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