 | | Vol. 16.04 – 2 February, 2024 |
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| The authors identified the SNF2-family DNA translocase SMARCAL1 as a factor that favored tumor immune evasion by a dual mechanism involving both the suppression of innate immune signaling and the induction of PD-L1-mediated immune checkpoint responses.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that inhibitor of DNA binding protein 2 (Id2) transcriptionally and epigenetically regulated the generation of Slamf6+ progenitor exhausted T cells and their conversion to Tim-3+ terminally exhausted cells.
[Science Immunology] |
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| Investigators reported that a sulfated bile acid, cholic acid 7-sulfate, bound to the nonclassical MHC class I protein MR1 and was recognized by mucosal-associated invariant T (MAIT) cells.
[Science Immunology] |
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| Scientists dissected heterologous donor-reactive memory CD8 T cell proliferation and their effector functions following infiltration into heart allografts having low or high intensities of ischemic inflammation.
[Journal Of Clinical Investigation] |
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| The authors generated α-thalassemia retardation X-linked (ATRX)-deficient glioma models in the presence and absence of the isocitrate dehydrogenase (IDH1)R132H mutation.
[Nature Communications] |
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| Scientists used photoconvertible mice to precisely track dendritic cell (DC) migration.They reported that CCR7+ DCs were the dominant DC population that migrated to the draining lymph node.
[Nature Communications] |
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| In vivo ablation of Kidins220 in B cells resulted in a marked reduction of λ light chain-expressing B cells, and Kidins220 knockout B cells failed to open and recombine the genes of the Igl locus, even in genetic scenarios where the Igk genes could not be rearranged or where the κLC conferred autoreactivity.
[eLife] |
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| Scientists showed that the N-linked glycosylation at residue 105 in the first immunoglobulin-like domain of CD155 was involved in the binding of CD155 to both DNAM-1 and tyrosine-based inhibitory motif domain.
[International Immunology] |
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| Researchers showed that loss of one of the most highly expressed deubiquitylating enzymes, Otub1, resulted in changes in murine splenic B cell subsets, leading to a significant increase in marginal zone and transitional B cells and a concomitant decrease in follicular B cells.
[Molecular and Cellular Biology] |
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| The authors summarize current clinical trials of antitumor NK cell therapy, provide an overview of innovative strategies for reprogramming NK cells, and also discuss some potential combination therapies.
[Molecular Therapy] |
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| Sanofi is paying $40 million to add another cytokine—IL-10—to its hit list. This has secured Sanofi the chance to work with Synthekine to overcome long-standing barriers to the use of the cytokine in the treatment of inflammatory diseases.
[Fierce Biotech] |
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| February 24 – 25, 2024
Galveston, Texas, United States |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Rutgers Health – Newark, New Jersey, United States |
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| | Texas A&M University – College Station, Texas, United States |
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| | University Hospital of Muenster – Münster, Germany |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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