 | | Vol. 16.05 – 9 February, 2024 |
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| Scientists showed that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), was increased in the serum of humans with major depressive disorder as well as in stress-susceptible mice following chronic social defeat stress.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers systematically screened the effects of 71 mutations from T cell neoplasms on T cell signaling, cytokine production, and in vivo persistence in tumors.
[Nature] |
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| Investigators examined the impact of the microbiota on tuft cell biology in the intestine. Succinate induction of tuft cells and type 2 innate lymphoid cells was elevated with loss of gut microbiota.
[Immunity] |
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| The authors used an adeno-associated virus–based CRISPR-Cas9 system with an inhibitor of nonhomologous end joining to repair such mutations in potentially long-lived T cells ex vivo.
[Science Immunology] |
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| Mice that were administered with doxorubicin received treadmill running exercise. The adoptive transfer of exercise-derived splenic B cells to μMT−/− (B cell–deficient) mice was performed to elucidate the mechanism of B cell regulation that mediated the effect of exercise.
[Circulation Research] |
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| Investigators reported that the mitochondrial protein, C15ORF48, was a critical inducer of stress-independent autophagy.
[Nature Communications] |
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| Scientists everaged two common forms of autoimmune encephalitis, mediated by leucine-rich glioma inactivated-1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies, as human models to comprehensively reconstruct and profile cerebrospinal fluid B cell receptor characteristics.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers explored the effect and molecular mechanisms of cathepsin D in the tumor microenvironment.
[Experimental & Molecular Medicine] |
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| The authors investigated how relatively weak or strong tonic T cell receptor signals influence naive CD8+ T cell responses to stimulation with foreign antigens.
[Science Signaling] |
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| Investigators provide an overview of the immune mechanisms that underpin the pathogenesis of type 1 diabetes, with a particular emphasis on T cells.
[Nature Reviews Immunology] |
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| The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease.
[Trends in Molecular Medicine] |
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| China and the United States will once again probably delay the renewal of a decades-old pact to cooperate on science and technology. The two nations have been negotiating for the past six months, but need more time to settle new terms and conditions requested by both sides, sources tell Nature.
[Nature News] |
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| A research-technology firm has developed a new approach to help identify journal articles that originate from paper mills — companies that churn out fake or poor-quality studies and sell authorships.
[Nature News] |
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| February 26 – 27, 2024
Manipal, India |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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| | University College London – London, England, United Kingdom |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Rutgers Health – Newark, New Jersey, United States |
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