 | | Vol. 16.06 – 16 February, 2024 |
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| Biotin-switch assay combined with liquid chromatography–tandem mass spectrometry was performed to identify the S-nitrosylated proteins in aortic tissue from both patients undergoing surgery for aortic dissection and Apoe−/− mice infused with angiotensin II.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found tumor-associated macrophages to be the main source of IL-23 in mouse and human tumor microenvironments.
[Nature Immunology] |
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| Scientists found that Bcl6 deficiency in αβ T cells resulted in the near absence of TCRαβ+CD8αα+ intraepithelial lymphocytes.
[Science Immunology] |
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| Investigators showed in a mouse tumor model representative of human lymphocyte-depleted cancer that radiotherapy enhanced spontaneous priming of thymus-derived regulatory T cells by the tumor.
[Journal Of Clinical Investigation] |
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| Researchers undertook a comprehensive preclinical study comparing the therapeutic potential of T cells either expressing second-generation anti-B cell maturation antigen (BCMA) CARs or secreting BCMAxCD3 T cell engagers in a T cell–limiting experimental setting.
[Science Translational Medicine] |
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| The authors generated mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP infected the mouse germline to analyze the role of genetic, epigenetic, and cell intrinsic restriction factors in endogenous retrovirus activation and control.
[Nature Communications] |
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| Investigators developed an experimental system to investigate cognate CD4+ and CD8+ T cell responses to a model-antigen expressed de novo in hepatocytes.
[Nature Communications] |
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| Immature myeloid cells were obtained from healthy bone marrow and co-cultured with activated T cells. The proliferation and apoptotic rate of the later were analyzed with Tag-it Violet.
[Journal of Neuroinflammation] |
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| Using tissue-plasminogen activator-deficient mice, investigators have analyzed the effect of lipopolysaccharide challenge on the phenotype of myeloid cells including neutrophils, macrophages, and dendritic cells in the spleen.
[Journal of Inflammation] |
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| Autoimmune disease heritability is enriched in T cell-specific regulatory regions of the genome. Modern-day T cell datasets now enable association studies between single nucleotide polymorphisms and a myriad of molecular phenotypes.
[Nature Communications] |
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| The authors discuss how endothelial cells regulate the migration and the functions of T cells in the CNS both at steady-state and in murine models of neuroinflammation, with a special focus on the anatomical, cellular, and molecular mechanisms implicated in EAE.
[European Journal of Immunology] |
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| Iovance Biotherapeutics, Inc. announced that the US FDA has approved AMTAGVI™ (lifileucel) suspension for intravenous infusion.
[Iovance Biotherapeutics, Inc.] |
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| March 13 – 16, 2024
Davos, Switzerland |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | UC Davis – Davis, California, United States |
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| | RMIT University – Melbourne, Australia |
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| | Queens University Belfast – Belfast, Ireland, United Kingdom |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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