Immune Regulation News Volume 16.07 | Feb 23 2024

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    Noshin Noorjahan
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    2024-02-23 | IRN 16.07


    Immune Regulation News by STEMCELL Technologies
    Vol. 16.07 – 23 February, 2024
    TOP STORY

    B Cells Orchestrate Tolerance to the Neuromyelitis Optica Autoantigen AQP4

    Scientists showed that B cells endogenously expressed AQP4 in response to activation with anti-CD40 and IL-21 and were able to present their endogenous AQP4 to T cells with an AQP4-specific T cell receptor.
    [Nature]

    Full ArticlePress Release
    PUBLICATIONSRanked by the impact factor of the journal

    Immunoengineering Can Overcome the Glycocalyx Armor of Cancer Cells

    The authors reported how cancer-associated mucins and their glycosylation contributed to the nanoscale material thickness of the glycocalyx and consequently modulated the functional interactions with cytotoxic immune cells.
    [Nature Materials]

    Abstract

    Targeting JMJD1C to Selectively Disrupt Tumor Treg Cell Fitness Enhances Antitumor Immunity

    Researchers showed that JMJD1C, a histone demethylase upregulated by cytokines in the tumor microenvironment, was essential for tumor Treg cell fitness but dispensable for systemic immune homeostasis.
    [Nature Immunology]

    Abstract

    STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

    Using a polymeric STING-activating nanoparticle with a shock-and-lock dual activation mechanism, investigators showed that conventional type 1 dendritic cells were essential for STING-mediated rejection of multiple established and metastatic murine tumors.
    [Science Immunology]

    Abstract

    UFL1 Ablation in T Cells Suppresses PD-1 UFMylation to Enhance Anti-Tumor Immunity

    Researchers reported that mice with conditional knockout (cKO) Ufl1 in T cells exhibit effective tumor control. Single-cell RNA sequencing analysis showed that tumor-infiltrating cytotoxic CD8+ T cells were increased in Ufl1 cKO mice.
    [Molecular Cell]

    AbstractGraphical Abstract

    Regenerating Murine CD8+ Lung Tissue Resident Memory T Cells after Targeted Radiation Exposure

    Investigators found that sublethal thorax-targeted radiation resulted in the rapid and prolonged numerical decline of influenza A virus–specific lung tissue-resident memory T cells (TRM)in mice, but no decline in antigen-matched circulating memory T cells.
    [Journal of Experimental Medicine]

    Abstract

    DUSP4 Modulates RIG-I- and STING-Mediated IRF3-Type I IFN Response

    The authors identified a critical regulatory function of the DUSP4 phosphatase in innate immune signaling. They found that DUSP4 regulated the activation of TBK1 and ERK1/2 in a signaling complex containing DUSP4, TBK1, ERK1/2, and IRF3 to regulate the production of type I interferons.
    [Cell Death & Differentiation]

    Full Article

    Bone Morphogenic Protein-4 Availability in the Cardiac Microenvironment Controls Inflammation and Fibrosis in Autoimmune Myocarditis

    Scientists found that bone morphogenic protein-4 gradients maintained cardiac tissue homeostasis by single-cell transcriptomics analyses of inflamed murine and human myocardial tissues.
    [Nature Cardiovascular Research]

    Full Article

    Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution

    Thrombosis was induced by inferior vena cava stenosis through ligation in mice. After 1 day, a P-selectin-blocking antibody or isotype control was administered and thrombus composition and resolution were analyzed.
    [Arteriosclerosis Thrombosis And Vascular Biology]

    Abstract

    Potentiating the Radiation-Induced Type I Interferon Anti-Tumoral Immune Response by ATM Inhibition in Pancreatic Cancer

    The authors evaluated the effects of AZD1390 or a structurally related compound AZD0156 on innate immune signaling and found that both inhibitors enhanced radiation-induced type I interferon expression via the POLIII/RIG-I/MAVS pathway.
    [JCI Insight]

    AbstractGraphical Abstract
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    REVIEWS

    The Regulation and Differentiation of Regulatory T Cells and Their Dysfunction in Autoimmune Diseases

    Investigators discuss the origins of Treg cells in the periphery and the multilayered mechanisms by which Treg cells are induced, as well as the FOXP3-dependent and FOXP3-independent cellular programmes that maintain the suppressive function of Treg cells in humans and mice.
    [Nature Reviews Immunology]

    Abstract

    The ConneXion between Sex and Immune Responses

    Scientists review the sex differences in immune system composition and function, examining how hormones and genetics influence the immune system.
    [Nature Reviews Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA Misses Congressional Deadline to Update Clinical Trial Diversity Guidance

    The US FDA is several weeks late in issuing guidance on how and when drug and device companies must submit diversity action plans for clinical trial research.
    [Regulatory Affairs Professionals Society]

    Press Release
    FEATURED EVENT

    2024 Biotherapeutics and Vaccines Development Conference GRC

    March 17 – 22, 2024
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    JOB OPPORTUNITIES

    Research Associate – Immunophenotyping of Tumor Microenvironment

    Cedars-Sinai – Los Angeles, California, United States

    Research Assistant – Microbial Biochemistry and Pathogenesis

    Queen’s University Belfast – Belfast, Ireland, United Kingdom

    Postdoctoral Researcher – Biology

    Maynooth University – Maynooth, Ireland, United Kingdom

    Postdoctoral Scientist – Liver Cancer Immunology

    Foundation for Liver Research – London, England, United Kingdom

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

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