 | | Vol. 16.08 – 1 March, 2024 |
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| Scientists reported that N6-methyladenosine (m6A) was an adaptive β-cell safeguard mechanism that controlled the amplitude and duration of the antiviral innate immune response at type 1 diabetes onset.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| High-throughput RNA sequencing was performed using human monocyte samples from controls and diabetes.
[Circulation Research] |
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| The authors engineered artificial antigen presenting cells with optimized size, stiffness and activation signals to induce human and mouse CD8+ T memory stem cells in vitro.
[ACS Nano] |
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| Researchers showed that modeling of intermittent ceralasertib treatment in mouse tumor models revealed CD8+ T-cell dependent antitumor activity, which was separate from the effects on tumor cells.
[Nature Communications] |
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| Investigators showed that cancer cell–targeted nanoliposomes that inhibited sequential steps of exosome biogenesis and released from lung cancer cells block the differentiation of lung fibroblasts into cancer associated fibroblasts.
[Science Advances] |
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| The authors established a human leukocyte antigen-I-matched humanized patient-derived xenograft hepatocellular carcinoma (HCC) model and three murine orthotopic HCC models to study the function of IL-37 in the tumor microenvironment.
[Cell Reports] |
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| Mechanistically, extracellular acidification significantly impeded T cell motility by suppressing podosome formation.
[Cell Reports] |
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| Scientists demonstrated that mAb43 binds to exocytotic sites on the β-cell surface, masking the antigenic exposure of ZnT8 and insulin following glucosestimulated insulin secretion.
[Diabetes] |
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| Researchers investigated the RUNX1 mediated crosstalk between tumor cells and M2 polarized tumor associated macrophages (TAMs) in colorectal cancer, as well as its relationship with neoplastic angiogenesis.
[Biomarker Research] |
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| The authors review how the integration of single-cell and spatial multi-omics data with prior knowledge allows us to obtain functional insights, focusing on gene regulatory processes and cell–cell interactions.
[Nature Immunology] |
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| Early last year, MD Anderson Cancer Center leadership had a contentious dispute between one of its most powerful researchers and a junior scientist over authorship, credit, and charges of verbal abuse. High-ranking officials at the cancer center tried — and failed — to resolve the feud.
[STAT News] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Queen’s University Belfast – Belfast, Ireland, United Kingdom |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | UC Davis – Davis, California, United States |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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