 | | Vol. 16.09 – 15 March, 2024 |
| |
|
|
| Investigators conducted studies using a novel mouse model and clinical correlative analysis to assess whether T cell help contributed to rituximab-mediated nature killer cell antibody-dependent cellular cytotoxicity in the tumor microenvironment in vivo.
[Blood] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists identified Mi-2β as a key melanoma-intrinsic effector regulating the adaptive anti-tumor immune response. Studies in genetically engineered mouse melanoma models indicated that loss of Mi-2β rescued the immune response to immunotherapy in vivo.
[Nature Communications] |
|
|
|
| Researchers reported findings from preclinical studies characterizing pharmacology, pharmacokinetics/pharmacodynamics, and safety profile of RO7502175, an afucosylated antibody designed to eliminate C–C motif chemokine receptor 8 (CCR8)+ Treg cells in the tumor microenvironment.
[British Journal Of Pharmacology] |
|
|
|
| Using data from single-cell RNA sequencing and flow cytometry, scientists initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with systemic lupus erythematosus.
[European Journal Of Immunology] |
|
|
|
| Investigators discovered an anti-human IL-2 antibody and engineered a covalently-linked single-agent fusion of human IL-2 and its antibody that selectively expanded Treg cells and exhibited superior disease control activity in animal models of ulcerative colitis and systemic lupus erythematosus.
[Communications Biology] |
|
|
|
| Scientists investigated the expression and regulation of human leukocyte antigen-II in human glioblastoma samples and the correlation with LAG-3+CD4+ T cell infiltration.
[Cancer Science] |
|
|
|
| Researchers explored the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models.
[Cancer Cell International] |
|
|
|
| Investigators constructed a novel Tregs-associated biomarker for the prediction of tumor immune microenvironment, clinical outcomes, and individualized treatment in hepatocellular carcinoma.
[Aging] |
|
|
|
| Scientists looked into the effect of Dioscin on the functions of CD4+ CD25+ Tregs in the aplastic anemia mouse model and explored its underlying mechanism.
[Hematology] |
|
|
|
|
| The authors review emerging evidence demonstrating unexpected roles for T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) as a key regulator of myeloid cell function.
[Science Immunology] |
|
|
|
|
| GRI Bio, Inc. announced that the Canadian Intellectual Property Office has issued a notice of allowance for Patent Application No. 3,007,970. The patent will cover claims including compositions and methods for modulating type 2 and/or type 1 cells in the prevention and treatment of inflammatory conditions of the liver.
[GRI Bio, Inc. (BioSpace)] |
|
|
|
|
| April 9 – 12, 2024
Fairmont Banff Springs, Alberta, Canada |
|
|
|
|
|
| | Genentech – San Francisco, California, United States |
|
|
|
| | University of Denmark – Lyngby, Denmark |
|
|
|
| | Foundation for Liver Research – London, England, United Kingdom |
|
|
|
| | Georg-Speyer-Haus – Frankfurt, Germany |
|
|
|
| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
