 | | Vol. 16.11 – 5 April, 2024 |
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| Scientists showed that ablation of the NaV1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grew into injured skin and muscle tissues and signaled to immune cells through the neuropeptide calcitonin gene-related peptide (CGRP).
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that tuberculosis severity was increased in toll-interacting protein (Tollip)−/− mice, characterized by macrophage- and T cell-driven inflammation, foam cell formation, and lipid accumulation.
[Nature Microbiology] |
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| Researchers performed single-cell RNA-Seq on non-human primate and patient-derived T cells to identify the phenotypic and transcriptomic hallmarks of bystander activation of CARneg T cells following B cell targeted CAR-T cell therapy.
[Blood] |
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| Investigators showed that mice heterozygous for an Ikbkb gain-of-function mutation develop psoriasis. Doubling the gene dose results in dactylitis, spondylitis, and characteristic nail changes, which are features of psoriatic arthritis.
[Nature Communications] |
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| The authors demonstrated that the methylation signatures of distinct biological processes were associated with immune activity in the cancer microenvironment and predict immunotherapy response.
[Genome Medicine] |
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| Investigators explored whether docosahexaenoic acid (DHA), a type of ω-3 PUFA, had an immunomodulatory role in promoting tumor growth in immunocompetent mice. The number of natural killer (NK) cells but not the number of T or B cells was decreased by DHA supplementation in various tissues.
[Cancer Immunology Research] |
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| Scientists showed that type III interferon (IFN-λ) was highly upregulated during human metapneumovirus infection in vitro in human and mouse airway epithelial cells and in vivo in mice. They found through several immunological and molecular assays that type II alveolar cells are the primary producers of IFN-λ.
[mBio] |
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| Investigators identified the inhibitory molecular mechanisms of metformin on programmed death ligand 1 expression in cancer cells and programmed death 1 expression in immune cells.
[Annals Of Laboratory Medicine] |
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| Researchers employed single-cell analysis to unveil the intricate nature of Tregs in human melanoma. Pseudotime and cell–cell interconnection analyses were conducted, followed by an endeavor to construct a prognostic model grounded in Treg-associated risk scores.
[Environmental Toxicology] |
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| Scientists observed that the role of the innate immune pathway demonstrated heterogeneity, linked to the tumor development stage, pathway status, and specific cell types. They proposed that within the tumor microenvironment, the innate immune pathway exhibited multidimensional diversity.
[Signal Transduction And Targeted Therapy] |
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| Early success in the first transplant of a pig kidney into a living person has raised researchers’ hopes for larger clinical trials involving pig organs. Such trials could bring ‘xenotransplantation’, the use of animal organs in human recipients, into the clinic.
[Nature] |
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| April 22 – 25, 2024
Banff, Alberta, Canada |
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| | University of Oslo – Oslo, Norway |
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| | University of Manitoba – Winnipeg City, Manitoba, Canada |
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| | Vanderbilt University – Bethesda, Maryland, United States |
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| | NYU Langone Health – New York City, New York, United States |
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| | Universitätsklinikum Köln – Cologne, Germany |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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Pulmonary Cell News
