 | | Vol. 16.14 – 26 April, 2024 |
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| Researchers found that SARS-CoV-2 evaded NKG2D recognition by surface downregulation of MIC-A/B via shedding, observed in human lung tissue and COVID-19 patient serum.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors studied the role of the Notch ligand Jagged2 on immune evasion in NSCLC. Higher expression of JAG2 in NSCLC negatively correlated with survival.
[Immunity] |
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| Scientists demonstrated that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, caused metabolite dihydrobiopterin (BH2) accumulation and decreased the ratio of tetrahydrobiopterin to BH2 in pancreatic ductal adenocarcinomas.
[Cell Metabolism] |
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| Investigators showed that NLR family CARD Domain Containing 4 (NLRC4) was downregulated in epithelial tumor cells of colorectal cancer patients by using spatial tissue imaging.
[Journal Of Clinical Investigation] |
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| By specific deletion of Rictor in CD11c+ myeloid cells, researchers investigated the role of mTOR complex 2 (mTORC2) signaling in dendritic cell function in mice.
[Journal of Leukocyte Biology] |
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| The authors investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. They found that tumor necrosis factor–α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression of a metabolic transcriptome.
[Science Signaling] |
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| Scientists investigated the potential of extracellular vesicles derived from human gingival mesenchymal stem cells as a therapeutic strategy for rheumatoid arthritis.
[JCI Insight] |
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| Investigators revealed that, in zebrafish hematopoiesis, L-threonine dehydrogenase (tdh) was preferentially expressed in neutrophils.
[FEBS Journal] |
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| Scientists review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris.
[Journal of Cellular Physiology] |
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| The authors focus on the role of CD39 and CD73 in immune response and malignant progression, including the expression of CD39 within the tumor microenvironment, its relationship to immune effector cells, and its role in antigen presentation.
[Future Oncology] |
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| Dr. Ashley Nelson has received a 2023 Hartwell Individual Biomedical Research Award from The Hartwell Foundation. The award provides $100,000 direct cost support per year for three years and designation as a Hartwell Investigator.
[Weill Cornell Medicine] |
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| May 5 – 7, 2024
Novato, California, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | University of Duisburg-Essen – Duisburg-Essen, Germany |
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| | University of Duisburg-Essen – Duisburg-Essen, Germany |
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| | Boston University – Boston, Massachusetts, United States |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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