CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue
In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. Strikingly, >95% of these dying cells are not productively infected but instead correspond to bystander cells. Researchers now show that the death of these “bystander” cells involves abortive HIV infection. [Cell]
Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-Like B Cells
Marginal zone (MZ) B cells of the spleen and B1 cells, termed innate-like B cells, differ from follicular B cells by their attenuated Ca2+ mobilization, fast antibody secretion, and increased cell adhesion. Researchers identified and characterized Mzb1 as an endoplasmic reticulum-localized and B cell-specific protein that was most abundantly expressed in MZ B and B1 cells. [Immunity]
Endogenous Cortisol and TGF-Beta in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function
Aqueous humor (AqH) has been shown to have significant immunosuppressive effects on APCs in animal models. Researchers wanted to establish whether, in humans, AqH can regulate dendritic cell function and to identify the dominant mechanism involved. [J Immunol]
Distinct Roles for the NK Cell-Activating Receptors in Mediating Interactions with Dendritic Cells and Tumor Cells
This study investigates the interaction of NK cells with dendritic cells and tumor cells, and the role of specific NK cell-activating receptors in this process. [J Immunol]
Cannabinoid Receptor Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Potent Immunosuppressive Properties
Here, researchers show that administration of delta9-tetrahydrocannabinol in mice leads to rapid and massive expansion of CD11b(+)Gr-1(+) myeloid-derived suppressor cells expressing functional arginase and exhibiting potent immunosuppressive properties both in vitro and in vivo. [Eur J Immunol]
Regulatory T Cells Predict the Time to Initial Treatment in Early Stage Chronic Lymphocytic Leukemia
Higher regulatory T cell levels had significant and independent prognostic power for predicting the time to initial treatment in patients with low to intermediate stage chronic lymphocytic leukemia. [Cancer]
Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis
By spectral imaging analysis of double-stained skin sections researchers demonstrated that IL-17 was mainly expressed by mast cells and neutrophils and IL-22 by macrophages and dendritic cells. [PLoS ONE]
The Canonical BMP Signaling Pathway is Involved in Human Monocyte-Derived Dendritic Cell Maturation
In this study, researchers investigate the effects of bone morphogenetic protein signaling activation on the capacity of human dendritic cells to stimulate immune responses. [Immunol Cell Biol]
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EVENTS (Listed by Date)
American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States
Vaccines Europe 2010
December 1-2, 2010
London, United Kingdom
Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States
5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States
Safety Symposium organized by the NIH RAC and Co-hosted by CliniGene: Retroviral and Lentiviral Vectors for Long-Term Gene Correction: Clinical Challenges in Vector and Trial Design
December 9-10, 2010
Bethesda, United States
The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States
Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States
Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States
AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States
Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States
Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States
Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Australia
18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States
The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States
2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States
Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States
GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary
American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States
Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy
DNA Vaccines 2011
July 12-14, 2011
San Diego, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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