Programming the Magnitude and Persistence of Antibody Responses with Innate Immunity Here researchers demonstrate that immunization of mice with synthetic nanoparticles containing antigens plus ligands that signal through Toll-like receptor (TLR) 4 and TLR7 induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with nanoparticles containing antigens plus a single TLR ligand. [Nature] IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology Mice infected with LCMV clone-13 have persistent high-level viremia and a dysfunctional immune response. Interleukin-7, a cytokine that is critical for immune development and homeostasis, was used here to promote immunity toward clone-13, enabling elucidation of the inhibitory pathways underlying impaired antiviral immune response. [Cell] Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity Researchers report two genetic etiologies of Chronic mucocutaneous candidiasis disease: autosomal recessive deficiency in the cytokine receptor, interleukin-17 receptor A (IL-17RA), and autosomal dominant deficiency of the cytokine IL-17F. [Science] Interbilayer-Crosslinked Multilamellar Vesicles as Synthetic Vaccines for Potent Humoral and Cellular Immune Responses Here, researchers describe interbilayer-crosslinked multilamellar vesicles formed by crosslinking headgroups of adjacent lipid bilayers within multilamellar vesicles. [Nat Mater] ROR(gamma)t+ Innate Lymphoid Cells Regulate Intestinal Homeostasis by Integrating Negative Signals from the Symbiotic Microbiota Here researchers show that in contrast to TH17 cells, both types of ROR(gamma)t+ innate lymphoid cells constitutively produced most of the intestinal IL-22 and that the symbiotic microbiota repressed this function through epithelial expression of IL-25. [Nat Immunol] Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response The contribution of Toll-like receptor (TLR) signaling to T cell-dependent antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. [Immunity] Exhaustive T-Cell Repertoire Sequencing of Human Peripheral Blood Samples Reveals Signatures of Antigen Selection and a Directly Measured Repertoire Size of at Least 1 Million Clonotypes From the error filtered data, researchers obtained 1,061,522 distinct TCRB nucleotide sequences. This figure establishes a new, directly measured lower limit on individual T-cell repertoire size and provides a useful reference set of sequences for repertoire analysis. [Genome Res] Therapeutical Targeting of Nucleic Acid-Sensing Toll-Like Receptors Prevents Experimental Cerebral Malaria Researchers provide evidence that supports the involvement of nucleic acid-sensing Toll-like receptors in malaria pathogenesis and that interference with the activation of these receptors is a promising strategy to prevent deleterious inflammatory responses that mediate pathogenesis and severity of malaria. [Proc Natl Acad Sci USA] Recombinant Human CD19-Ligand Protein as a Potent Anti-Leukemic Agent Researchers report the cloning and characterization of a novel 54-kDa high-mobility group-box protein as the ligand for the human pan-B cell co-receptor CD19, which interacts with the extracellular domain of CD19 in trans. [Br J Haematol] Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn’s Disease (CD). The finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans. [PLoS ONE] |