Immune Regulation News Volume 4.02 | Jan 20 2012

Rescued Tolerant CD8 T Cells Are Preprogrammed to Reestablish the Tolerant State
Using an in vivo mouse model, investigators show that tolerant T cells proliferate and become functional under lymphopenic conditions, even in a tolerogenic environment. [Science] Abstract

An Essential Role for T_H2-Type Responses in Limiting Acute Tissue Damage during Experimental Helminth Infection
These studies indicate an essential role for T_H2-type immune responses in mediating acute wound healing during helminth infection. [Nat Med] Abstract | Press Release

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8⁺ T Cell Phenotypes
By using metal-labeled probes and mass spectrometric analysis (cytometry by time-of-flight) of human CD8⁺ T cells, researchers analyzed the expression of many more proteins than previously possible with fluorescent labels, including surface markers, cytokines, and antigen specificity with modified peptide-MHC tetramers. [Immunity] Abstract

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation
Investigators show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop natural killer cells. [Immunity] Abstract

Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells
Mycobacterium tuberculosis promotes its replication by inhibiting the apoptosis of infected macrophages. Researchers show that M. tuberculosis also suppresses neutrophil apoptosis. [Cell Host Microbe] Abstract

Dickkopf-3, an Immune Modulator in Peripheral CD8 T-Cell Tolerance
To determine the molecular basis of peripheral CD8 T-cell tolerance, researchers exploited a double transgenic mouse model in which CD8 T cells are neonatally tolerized following interaction with a parenchymal self-antigen. [Proc Natl Acad Sci USA] Abstract

CD4 and CD8 T Cells Require Different Membrane Gangliosides for Activation
While investigating T-cell activation in ganglioside-deficient mice, scientists observed that CD4⁺ and CD8⁺ T cells required different ganglioside subsets for activation. [Proc Natl Acad Sci USA] Abstract

Toll-Like Receptor 3 Signaling Converts Tumor-Supporting Myeloid Cells to Tumoricidal Effectors
Researchers find that the Toll-like receptor 3/Toll–IL-1 receptor domain-containing adaptor molecule 1 pathway is not only important to mature myeloid dendritic cells for cross-priming and natural killer cell activation in the induction of tumor immunity, but also critically engaged in tumor suppression by converting tumor-supporting macrophages to those with tumoricidal properties. [Proc Natl Acad Sci USA] Abstract

Morbid Obese Human Subjects Have Increased Peripheral Blood CD4⁺ T Cells with Skewing Toward a T-Regulatory- and T-Helper 2-Dominated Phenotype
In this study, researchers investigated the peripheral blood T-cell compartment of morbid obese and lean subjects. [Diabetes] Abstract

Tetracyclines Convert the Osteoclastic-Differentiation Pathway of Progenitor Cells to Produce Dendritic Cell-Like Cells
Osteoclasts and dendritic cells (DCs) are derived from common progenitors, such as bone marrow-derived macrophages. In this article, researchers show that tetracyclines convert the differentiation pathway, resulting in DC-like cells not osteoclasts. [J Immunol] Abstract

CD69 Regulates Type I IFN-Induced Tolerogenic Signals to Mucosal CD4 T Cells That Attenuate Their Colitogenic Potential
Scientists aimed to investigate the role of CD69 in mucosal immune responses. The expression of CD69 by CD4 T cells isolated from the spleen, mesenteric lymph nodes, small intestinal lamina propria, and colonic lamina propria was determined in specific pathogen-free B6 and TCR transgenic animals, as well as in germ-free B6 mice. [J Immunol] Abstract

Oregon Health & Science University Vaccine and Gene Therapy Institute Receives Grant for AIDS Vaccine Development
Researchers at Oregon Health & Science University’s Vaccine and Gene Therapy Institute have been awarded an $8 million grant from the Bill & Melinda Gates Foundation to further develop a promising HIV vaccine candidate to combat the worldwide AIDS epidemic. [Oregon Health & Science University] Press Release

TapImmune to Open New Laboratories and Offices at 1551 Eastlake Ave. Comprehensive Lab Facilities Located in Seattle’s Newest Biotech Hub
TapImmune Inc. has signed a sub-lease for newly-renovated, state of the art laboratory and office space at 1551 Eastlake Avenue in South Lake Union – in the heart of Seattle’s vibrant biotech and medical community. [TapImmune Inc.] Press Release

Otsuka Pharmaceutical and UCB Focus Collaboration in the Area of Central Nervous System (CNS) Disorders
Otsuka Pharmaceutical Co., Ltd. and UCB announced that the companies have agreed to focus their collaboration on the therapeutic area of CNS disorders and to discontinue their collaboration in immunology. [Otsuka Pharmaceutical Co., Ltd.] Press Release

CIFAR Announces Dr. Alan Bernstein, O.C. As New President and CEO
On behalf of the Board of the Canadian Institute for Advanced Research (CIFAR), David Dodge announced the appointment of Dr. Alan Bernstein as the Institute’s new President and CEO. [Canadian Institute for Advanced Research] Press Release

Leadership Group for a Clinical Research Network on Antibacterial Resistance (UM1) (RFA-AI-12-019) [National Institutes of Health, United States]

Limited Competition: Continuation of the Clinical Islet Transplantation (CIT) Consortium Data Coordinating Center (U01) (RFA-DK-12-501) [National Institutes of Health, United States]

Center For Scientific Review: Notice of Closed Meetings (FR Doc No: 2012-375) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Molecular Medicine Tri-Conference 2012
February 19-23, 2012
San Francisco, United States

NEW Cell Culture World Congress
February 28-March 1, 2012
Munich, Germany

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