Immune Regulation News Volume 4.15 | Apr 27 2012

Nonclassical Major Histocompatibility Complex Class Ib-Restricted Cytotoxic T Cells Monitor Antigen Processing in the Endoplasmic Reticulum
Researchers report that nonclassical Qa-1^b-peptide complexes direct cytotoxic T cells to targets with defective antigen processing in the endoplasmic reticulum. [Nat Immunol] Abstract

Nitric Oxide Increases Susceptibility of Toll-Like Receptor-Activated Macrophages to Spreading Listeria monocytogenes
Researchers showed that Toll-like receptor-activated macrophages killed cell-free Listeria monocytogenes (Lm) but failed to prevent infection by spreading Lm. [Immunity] Abstract

LTB₄ Is a Signal-Relay Molecule during Neutrophil Chemotaxis
Scientists demonstrated that leukotriene B₄ (LTB₄) plays a central role in neutrophil activation and migration to formyl peptides. [Dev Cell] Abstract

The Differential Production of Cytokines by Human Langerhans Cells and Dermal CD14⁺ DCs Controls Cytotoxic T Cell Priming
Researchers concluded that the respective production of IL-15 and IL-10 explains the contrasting effects of langerhans cells and dermal CD14⁺ DCs on CD8⁺ T cell priming. [Blood] Abstract

A Foundation for “Universal” T-Cell Based Immunotherapy: T-Cells Engineered to Express a CD₁₉-Specific Chimeric-Antigen-Receptor and Eliminate Expression of Endogenous T Cell Receptor 
Clinical-grade T-cells were genetically modified ex vivo to express a chimeric antigen receptor to redirect specificity to a tumor associated antigen, thereby conferring anti-tumor activity in vivo. [Blood] Abstract

Immune Activation and Increased Interleukin-21 Receptor Expression Are Associated with the Loss of Memory B Cells during HIV-1 Infection
By measuring markers of immune activation and molecules involved in apoptosis regulation, researchers evaluated the association between microbial translocation and loss of memory B cells in human immunodeficiency virus type-1 (HIV-1)-infected patients. [J Intern Med] Abstract

Mast Cell TLR2 Signaling Is Crucial for Effective Killing of Francisella tularensis
Researchers provided evidence for the important effector contribution of mast cells and TLR2-mediated signaling on early innate processes in the lung following pulmonary F. tularensis infection and provide additional insight into possible mechanisms by which intracellular pathogens modulate respiratory immune defenses. [J Immunol] Abstract

Staphylococcal Panton-Valentine Leukocidin Induces Pro-Inflammatory Cytokine Production and Nuclear Factor-Kappa B Activation in Neutrophils
The results of this study support growing evidence that neutrophils play an important role in the pathogenesis of Panton-Valentine leukocidin-induced tissue injury and inflammation. [PLoS One] Full Article

CD8⁺ T Cells from Mice Transnuclear for a T Cell Receptor that Recognizes a Single H-2K^b-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection
To study the CD8⁺ T cell response against a mouse γ-herpes virus, researchers generated K^b-MHV-68-ORF8^604-612RAG^-/- CD8⁺ T cell receptor transnuclear mice as a source of virus-specific CD8⁺ T cells. [Cell Reports] Full Article

Lophius Biosciences Performs Successful Clinical Validation for T-Track^® CMV/EBV Test Systems
Lophius Biosciences announced the successful completion of a prospective multicenter clinical validation study for its T-Track® CMV/EBV tests. [Lophius Biosciences] Press Release

Novo Nordisk and Oxford University Team Up to Develop Novel Treatments for Rheumatoid Arthritis and Other Inflammatory Diseases
Novo Nordisk and the Kennedy Institute of Rheumatology at Oxford University jointly announced a new partnership to develop promising new drug candidates and identify novel biomarkers and treatment targets for rheumatoid arthritis and other autoimmune inflammatory diseases. [Novo Nordisk A/S] Press Release

Coronado Biosciences Announces Independent Data Monitoring Committee Recommendation to Continue Falk Phase II Trial of TSO in Crohn’s Disease
Coronado Biosciences, Inc. announced that it received from Dr. Falk Pharma GmbH (Falk), its development partner, a recommendation from the independent data monitoring committee that conducted an interim analysis (blinded to Falk) of clinical data from the initial 120 patients to continue Falk’s Phase II clinical trial in Europe evaluating Trichuris suis ova (TSO) in Crohn’s disease. [Coronado Biosciences, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the immune regulation community.

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)  

Cell Biologist – Innate Immune Response (Universitair Medisch Centrum)

Postdoctoral Position – Protein Chemistry/Immuno-Receptor Biology (South San Francisco, United States)


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