| TOP STORY | BACH2 Represses Effector Programs to Stabilize Treg-Mediated Immune Homeostasis By studying mice in which the Bach2 gene is disrupted, researchers defined BACH2 as a broad regulator of immune activation that stabilizes immunoregulatory capacity while repressing the differentiation programs of multiple effector lineages in CD4+ T cells. BACH2 was required for efficient formation of regulatory (Treg) cells and consequently for suppression of lethal inflammation in a manner that was Treg-cell-dependent. [Nature] Abstract | Press Release |
| PUBLICATIONS (Ranked by impact factor of the journal) | Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis Investigators showed that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival. When activated T cells are provided with costimulation and growth factors but are blocked from engaging glycolysis, their ability to produce IFN- is markedly compromised. [Cell] Abstract | Press Release | Video The Signaling Suppressor CIS Controls Proallergic T Cell Development and Allergic Airway Inflammation Scientists found that the SOCS protein CIS, which was substantially induced by interleukin 4, negatively regulated the activation of STAT3, STAT5 and STAT6 in T cells. CIS-deficient mice spontaneously developed airway inflammation, and CIS deficiency in T cells led to greater susceptibility to experimental allergic asthma. [Nat Immunol] Abstract Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals Investigators report that Foxp3 was lethal to developing regulatory T (Treg) cells in the thymus because it induced a unique proapoptotic protein signature (Puma++p-Bim++p-JNK++DUSP6–) and repressed expression of prosurvival Bcl-2 molecules. However, Foxp3 lethality was prevented by common gamma chain (γc)-dependent cytokine signals that were present in the thymus in limiting amounts sufficient to support only one million Treg cells. [Immunity] Abstract | Graphical Abstract Antigenic Liposomes Displaying CD22 Ligands Induce Antigen-Specific B Cell Apoptosis Researchers showed that liposomal nanoparticles, displaying both antigen and glycan ligands of the inhibitory coreceptor CD22, induce a tolerogenic program that selectively causes apoptosis in mouse and human B cells. [J Clin Invest] Full Article | Press Release Antigen-Specific, Antibody-Coated, Exosome-Like Nanovesicles Deliver Suppressor T-Cell MicroRNA-150 to Effector T Cells to Inhibit Contact Sensitivity Investigators examined the mechanism or mechanisms of immune suppression mediated by antigen-specific suppressive nanovesicles. T-cell tolerance was induced by means of intravenous injection of hapten conjugated to self-antigens of syngeneic erythrocytes and subsequent contact immunization with the same hapten. [J Allergy Clin Immunol] Abstract Protection of Islet Grafts through TGF Beta Induced Tolerogenic DC Scientists investigated the possibilities of transient expression of the immunosuppressive cytokine Transforming Growth Factor (TGF) beta within islets to achieve long term graft tolerance. They found that brief expression of TGF beta prevented rejection of syngeneic islets, that there was reduction of dendritic cell (DC) activation in the graft and reduced reactivation of T cells in the graft draining lymph nodes. [Diabetes] Abstract MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration Results indicated a central role for microglial MHCII in the activation of both the innate and adaptive immune responses to α-syn in Parkinson disease and suggested that the MHCII signaling complex may be a target of neuroprotective therapies for the disease. [J Neurosci] Abstract | Press Release Mediation of Protection and Recovery from Experimental Autoimmune Encephalomyelitis by Macrophages Expressing the Human Voltage-Gated Sodium Channel NaV1.5 Investigators previously demonstrated that a variant of the voltage-gated sodium channel NaV1.5 is expressed intracellularly in human macrophages, and that it regulates cellular signaling. This channel is not expressed in mouse macrophages, which has limited the study of its functions. To overcome this obstacle, they developed a novel transgenic mouse model, in which the human macrophage NaV1.5 splice variant is expressed in vivo in mouse macrophages. [J Neuropathol Exp Neurol] Abstract | Press Release Commensal Microbiota Are Required for Systemic Inflammation Triggered by Necrotic Dendritic Cells Scientists report that mice deficient for the Fas-associated death domain in dendritic cells (DCs) developed systemic inflammation associated with elevated proinflammatory cytokines and increased myeloid and B cells. These mice exhibited reduced DCs in gut-associated lymphoid tissues due to RIP3-dependent necroptosis, whereas DC functions remained intact. [Cell Rep] Abstract | Graphical Abstract | Full Article Don’t forget to subscribe to our sister publications: Human Immunology News and Immunology of Infectious Disease News! |
| REVIEWS | T Cell Regulation of Natural Killer Cells In light of their role in the immune response against tumors and viruses, natural killer (NK) cells represent a promising target for immunotherapy. Before this target is reached, the various mechanisms that control NK cell activity must first be identified and understood. [J Exp Med] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation field. |
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