Rapid Effector Function of Memory CD8+ T Cells Requires an Immediate-Early Glycolytic Switch Investigators showed that rapid interferon-γ production of effector memory CD8+ T cells, activated through stimulation mediated by the T cell antigen receptor and the costimulatory receptor CD28 or through cognate interactions, was linked to increased glycolytic flux. [Nat Immunol] Abstract The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3 Researchers demonstrated that stress signals elicited by proinflammatory cytokines and lipopolysaccharides lead to the degradation of Foxp3 through the action of the E3 ubiquitin ligase Stub1. Stub1 interacted with Foxp3 to promote its K48-linked polyubiquitination in an Hsp70-dependent manner. [Immunity] Abstract | Graphical Abstract Tristetraprolin Regulation of Interleukin 23 mRNA Stability Prevents a Spontaneous Inflammatory Disease Scientists explored the role of the adenine and uridine-rich element-binding protein tristetraprolin in influencing mRNA stability of interleukin (IL)12p35, IL12/23p40, and IL23p19 subunits. [J Exp Med] Abstract Lung Dendritic Cells Induce Migration of Protective T Cells to the Gastrointestinal Tract To explore alternative pathways of cellular migration, scientists investigated the ability of dendritic cells (DCs) from mucosal and nonmucosal tissues to recruit lymphocytes to the gastrointestinal (GI) tract. Unexpectedly, they found that lung DCs, like CD103+ mesenteric lymph node DCs, up-regulate the gut-homing integrin α4β7 in vitro and in vivo, and induce T cell migration to the GI tract in vivo. [J Exp Med] Abstract Differentiation and Functional Regulation of Human Fetal NK Cells The authors showed that fetal natural killer (NK) cells differentiate early in utero and are highly responsive to cytokines and antibody-mediated stimulation but respond poorly to HLA class I-negative target cells. Strikingly, expression of killer-cell immunoglobulin-like receptors did not educate fetal NK cells but rendered them hyporesponsive to target cells lacking HLA class I. [J Clin Invest] Full Article Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer Investigators showed that IP-10 secreted by breast cancer cells attracted γδ regulatory T (Treg) cells. Using neutralizing antibodies against chemokines secreted by breast cancer cells, they found that IP-10 was the only functional chemokine that causes γδ Treg cells to migrate toward breast cancer cells. [Cancer Res] Abstract Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior Scientists showed that repeated social defeat (RSD)-induced anxiety-like behavior corresponded with an exposure-dependent increase in circulating monocytes and brain macrophages. Moreover, RSD-induced anxiety-like behavior corresponded with brain region-dependent cytokine and chemokine responses involved with myeloid cell recruitment. [J Neurosci] Abstract | Press Release CTLA4Ig Inhibits Effector T Cells through Regulatory T Cells and TGF-β Researchers identified a novel, CD28-independent mechanism by which CTLA4Ig inhibits activated T cells. They showed that in vitro, CTLA4Ig synergizes with NO from bone marrow-derived macrophages to inhibit T cell proliferation. [J Immunol] Abstract
|