Fatty Acid-Induced Mitochondrial Uncoupling Elicits Inflammasome-Independent IL-1α and Sterile Vascular Inflammation in Atherosclerosis The authors found that atherogenesis was mediated by IL-1α and they identified fatty acids as potent inducers of IL-1α-driven vascular inflammation. Fatty acids selectively stimulated the release of IL-1α but not of IL-1β by uncoupling mitochondrial respiration. [Nat Immunol] Abstract Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes Researchers showed that Ly-6C+ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs). Entry was unaffected in gnotobiotic mice. Monocytes in resting lung and LN had similar gene expression profiles to blood monocytes but elevated transcripts of a limited number of genes including cyclo-oxygenase-2 and major histocompatibility complex class II, induced by monocyte interaction with endothelium. [Immunity] Abstract Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20 Investigators report that Ash1l, a H3K4 methyltransferase, suppressed interleukin-6, and tumor necrosis factor production in Toll-like receptor-triggered macrophages, protecting mice from sepsis. [Immunity] Abstract MicroRNA-146a Regulates Survival and Maturation of Human Plasmacytoid Dendritic Cells The authors investigated the role of microRNA-146a (miR-146a) in Toll-like-receptor (TLR) pathway regulation in human plasmacytoid dendritic cells (pDCs). They showed that miR-146a expression was induced upon TLR7/9 signaling. Furthermore, ectopic miR-146a expression effectively impaired TLR-mediated signaling in pDCs as TLR-induced NF-κB activation was reduced. [Blood] Abstract PDCD5 Negatively Regulates Autoimmunity by Upregulating FOXP3+ Regulatory T Cells and Suppressing Th17 and Th1 Responses Researchers demonstrated that PDCD5 interacts with FOXP3, increases acetylation of FOXP3 in synergy with Tip60 and enhances the repressive function of FOXP3. In PDCD5 transgenic mice, overexpression of PDCD5 enhanced the level of FOXP3 protein and percentage of CD4+CD25+FOXP3+ cells. [J Autoimmune] Abstract The Scaffold Protein Prohibitin Is Required for Antigen-Stimulated Signaling in Mast Cells The authors found that prohibitin (PHB) was abundant in the intracellular granules of mast cells, which are critical for allergic responses to antigens. Thus, they investigated whether PHB played a role in signaling mediated by the high-affinity receptor for antigen-bound immunoglobulin E, FcεRI. [Sci Signal] Abstract A Transient Reversal of miRNA-Mediated Repression Controls Macrophage Activation Investigators showed that there is a transient reversal of miRNA-mediated repression during the early phase of the inflammatory response in macrophages, which leads to the protection of cytokine mRNAs from miRNA-mediated repression. [EMBO Rep] Abstract CD8+ Cells Regulate the T Helper-17 Response in an Experimental Murine Model of Sjögren Syndrome This study investigated the regulatory function of CD8+ cells in T helper-17 cell-mediated corneal epithelial barrier disruption that develops in a murine desiccating stress model that resembles Sjögren syndrome. [Mucosal Immunol] Abstract Inactivation of Tumor-Specific CD8+ CTLs by Tumor-Infiltrating Tolerogenic Dendritic Cells Scientists found that Hepa1-6-1 had the ability to grow continuously after subcutaneous implantation into syngeneic C57BL/6 mice and did not prime CD8+ cytotoxic T lymphocytes (CTLs). In contrast, Hepa1-6-2 cells, which display reduced levels of adhesion molecules, such as Intercellular Adhesion Molecule 1, failed to grow in vivo and efficiently primed CTLs. [Immunol Cell Bio] Full Article
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