Microbiota-Dependent Crosstalk between Macrophages and Innate Lymphoid Cell 3 Promotes Intestinal Homeostasis Investigators demonstrated that deficient granulocyte macrophage colony-stimulating factor production altered mononuclear phagocyte effector functions and led to reduced regulatory T cell numbers and impaired oral tolerance. [Science] Abstract | Press Release Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death Scientists identified the inhibitory C-type lectin receptor Clec12a as a specific receptor for dead cells. Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate), which are key danger signals for cell-death-induced immunity. [Immunity] Abstract | Graphical Abstract | Press Release Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Researchers developed a suite of whole-blood, syringe-based assay systems that can be used to reproducibly assess induced innate or adaptive immune responses. By eliminating preanalytical errors associated with immune monitoring, they have defined the protein signatures induced by medically relevant bacteria, fungi, and viruses; agonists specific for defined host sensors; clinically employed cytokines; and activators of T cell immunity. [Immunity] Abstract | Press Release T Cell-Derived Interleukin (IL)-21 Promotes Brain Injury following Stroke in Mice Using a mouse model of transient focal brain ischemia, scientists report that IL-21 is highly up-regulated in the injured mouse brain after cerebral ischemia. IL-21-deficient mice have smaller infarcts, improved neurological function, and reduced lymphocyte accumulation in the brain within 24 hours of reperfusion. [J Exp Med] Abstract | Press Release FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Responses by Controlling IL-2 Availability Researchers tested the role of FoxP3+ regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal center B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, they find that Treg depletion severely reduces the Tfh cell response to influenza virus. [Nat Commun] Abstract CD31 Is a Key Coinhibitory Receptor in the Development of Immunogenic Dendritic Cells Researchers showed that CD31 is a key coinhibitory receptor on stimulated dendritic cells (DCs), favoring the development of tolerogenic functions and finally resulting in T-cell tolerance. The disruption of CD31 signaling favored the immunogenic maturation and migration of resident DCs to the draining lymph nodes. [Proc Natl Acad Sci USA] Abstract | Full Article Antitumor Effects of Cisplatin Combined with Tecemotide Immunotherapy in a Human MUC1 Transgenic Lung Cancer Mouse Model The authors aimed to define the effects of simultaneous cisplatin/ tecemotide therapy on tumor development in a human mucin 1 (MUC1) transgenic lung cancer mouse model; and examine the effects of radiation therapy on splenocytes, serum cytokines, and immune response to tecemotide. [Cancer Immunol Res] Abstract | Press Release Immune Privilege of the Central Nervous System Is Not the Consequence of Limited Antigen Sampling To compare antigen sampling from immune-privileged or nonprivileged tissues, scientists created transgenic mice with oligodendrocyte or gut epithelial cell expression of an EGFP-tagged fusion protein containing ovalbumin (OVA) antigenic peptides and tested peripheral anti-OVA peptide-specific sentinel OT-I and OT-II T cell activation. [Sci Rep] Full Article |