Immune Regulation News Volume 6.19 | May 30 2014

Rhbdd3 Controls Autoimmunity by Suppressing the Production of IL-6 by Dendritic Cells via K27-Linked Ubiquitination of the Regulator NEMO
Investigators report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the activation of dendritic cells and production of interleukin 6 triggered by Toll-like receptors. [Nat Immunol] Abstract

Generation of a New Therapeutic Peptide that Depletes Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
In multiple tumor models, intravenous peptibody (peptide-Fc fusion proteins) injection completely depleted blood, splenic and intratumoral myeloid-derived suppressor cells in tumor-bearing mice without affecting proinflammatory immune cell types, such as dendritic cells. [Nat Med] Abstract | Press Release

Regulatory T Cells Modulate Granulomatous Inflammation in an HLA-DP2 Transgenic Murine Model of Beryllium-Induced Disease
Using beryllium (Be)-loaded HLA-DP2-peptide tetramers, scientists identified Be-specific CD4⁺ T cells in the mouse lung that recognize identical ligands as CD4⁺ T cells derived from the human lung. [Proc Natl Acad Sci USA] Abstract | Full Article

Virus and Autoantigen-Specific CD4⁺ T Cells Are Key Effectors in a SCID Mouse Model of Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disorders
Injection of different virus-specific CD4⁺ T-cell clones showed that single specificities were capable of prolonging mouse survival and that the degree of tumor protection directly correlated with recognition of target cells in vitro. [PLoS Pathog] Full Article

A Role for Intrathymic B Cells in the Generation of Natural Regulatory T Cells
Mice with transgenic expression of BAFF harbor increased numbers of Helios⁺Foxp3⁺ thymic regulatory T cells and, similar to some human autoimmune conditions, also exhibit increased numbers of B cells colonizing the thymus. [J Immunol] Abstract

Differential Impact of CD27 and 4-1BB Costimulation on Effector and Memory CD8 T Cell Generation following Peptide Immunization
Researchers analyzed the CD8 T cell response elicited by two experimental vaccines comprising a peptide/protein Ag and an agonist that delivers a costimulatory signal via CD27 or 4-1BB. [J Immunol] Abstract

Molecular Signatures and Transcriptional Regulatory Networks of Human Immature Decidual NK and Mature Peripheral NK Cells
Investigators showed that many novel growth factors, cytokines, and chemokines are expressed by natural killer (NK) cells, and they may regulate NK-cell development or function in an autocrine manner. [Eur J Immunol] Abstract

Differential Regulation of Anti-Inflammatory Genes by p38 MAP Kinase and MAP Kinase Kinase 6
Investigators explored the mechanisms that preserve anti-inflammatory gene expression by evaluating differential regulation of IL-10 and p38-dependent anti-inflammatory genes in MKK3^−/−, MKK6^−/−, and p38 inhibitor-treated wildtype cells. [J Inflamm (Lond)] Full Article

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Aduro Announces License Agreement with Johnson & Johnson Innovation for Novel Immunotherapies for Prostate Cancer
Aduro BioTech, Inc. announced that it has entered into an agreement granting Janssen Biotech, Inc. an exclusive, worldwide license to certain product candidates specifically engineered for the treatment of prostate cancer based on its novel LADD immunotherapy platform. [Aduro BioTech, Inc. (Business Wire)] Press Release

Array BioPharma Announces Drug Discovery Collaboration Agreement with Biogen Idec
Array BioPharma announced a collaboration agreement with Biogen Idec for the discovery and development of inhibitors targeting a novel kinase for the treatment of autoimmune disorders. [Array Biopharma, Inc.]
Press Release

MacroGenics and Takeda Enter Strategic Alliance to Develop DART for Treatment of Autoimmune Disorders
MacroGenics, Inc. and Takeda Pharmaceutical Company Limited jointly announced that they have entered into an option agreement for the development and commercialization of MGD010. MGD010 is currently in pre-clinical development for the treatment of autoimmune diseases. [MacroGenics, Inc.]
Press Release

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Postdoctoral Position – Biology of Memory B Cells (Medical Research Council)

Postdoctoral Research Fellow – Allergic Lung Inflammation (Singapore Immunology Network)

Postdoctoral Position – Cell Death and Inflammation (Inflammation Research Center – VIB-UGent)

Postdoctoral Position – Cell and Extracellular Matrix Biology (Johns Hopkins University)

Principal Investigator – Molecular Mechanisms of Inflammation (Inflammation Research Center – VIB-UGent)

Postdoctoral Fellow – Microbiology and Immunology (McGill University)

Postdoctoral Research Associate – Functional Cross-Talk between T Lymphocytes and NK Cells (Meharry Medical College School of Medicine)

Postdoctoral Associate/Research Scientist – Macrophage Biology (Massachusetts Institute of Technology – MIT)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Research Position – Molecular and Cellular Mechanisms of Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

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