Activated T Cells Secrete an Alternatively Spliced Form of Common γ-Chain that Inhibits Cytokine Signaling and Exacerbates Inflammation Activated T cells produced an alternatively spliced form of γ-chain (γc) mRNA that resulted in protein expression and secretion of the γc extracellular domain. The soluble form of γc was present in serum and directly bound to IL-2Rβ and IL-7Rα proteins on T cells to inhibit cytokine signaling and promote inflammation. [Immunity] Abstract | Graphical Abstract Transplanted Terminally Differentiated Induced Pluripotent Stem Cells Are Accepted by Immune Mechanisms Similar to Self-Tolerance Scientists showed in murine models that autologous induced puripotent stem cell-derived endothelial cells elicit an immune response that resembles the one against a comparable somatic cell, the aortic endothelial cell. These cells exhibit long-term survival in vivo and prompt a tolerogenic immune response characterized by elevated IL-10 expression. [Nat Commun] Abstract | Press Release FcγRIIB Regulates T-Cell Autoreactivity, ANCA Production, and Neutrophil Activation to Suppress Anti-Myeloperoxidase Glomerulonephritis Transfer of FcγRIIB-deficient dendritic cells loaded with a nephritogenic myeloperoxidase peptide (MPO409-428) into wild-type mice induced stronger autoimmunity than dendritic cells derived from wild-type mice. [Kidney Int] Abstract Activation of mTOR Pathway in Myeloid-Derived Suppressor Cells Stimulates Cancer Cell Proliferation and Metastasis in lal−/− Mice Investigators report that myeloid-derived suppressor cells from lysosomal acid lipase-deficient (lal−/−) mice directly stimulated B16 melanoma cell in vitro proliferation and in vivo growth and metastasis. [Oncogene] Abstract Bovine γδ T Cells Are a Major Regulatory T Cell Subset Researchers provided evidence showing bovine γδ T cells are the major regulatory T cell subset in peripheral blood. These γδ T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF-β, and contact with APCs. [J Immunol] Abstract Antigen-Specific Thymocyte Feedback Regulates Homeostatic Thymic Conventional Dendritic Cell Maturation Cross-talk with thymocytes regulates thymic conventional dendritic cell (cDC) numbers, phenotype, and function. In mice lacking TCR-expressing thymocytes, thymic cDC were reduced and exhibited a less mature phenotype. [J Immunol] Abstract Early Treatment with Anti-VLA-4 Monoclonal Antibody Can Prevent the Infiltration and/or Development of Pathogenic CD11b+CD4+ T Cells in the CNS during Progressive EAE Investigators assessed the effects of anti-very late antigen (VLA)-4 monoclonal antibody therapy in a progressive experimental autoimmune encephalomyelitis (EAE) mouse model. They observed the accumulation of a novel subset of GM-CSF-producing CD11b+CD4+ T cells in the CNS throughout disease progression. [PLoS One] Full Article B7-H1 Signaling Is Integrated during CD8+ T Cell Priming and Restrains Effector Differentiation Using a brief in vitro priming model, researchers found that B7-H1 expressed by activated dendritic cells is integrated during priming of naïve CD8+ T cells and functions to limit the differentiation of effector T cell responses. [Cancer Immunol Immunother] Abstract Combination of an Agonistic Anti-CD40 Monoclonal Antibody and the COX-2 Inhibitor Celecoxib Induces Anti-Glioma Effects by Promotion of Type-1 Immunity in Myeloid Cells and T-Cells The combination therapy significantly increased the frequency of CD8+ T-cells, enhanced IFN-γ-production and reduced CD4+CD25+Foxp3+ T regulatory cells in the brain, and induced tumor-antigen-specific T-cell responses in lymph nodes. [Cancer Immunol Immunother] Abstract Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells Interleukin (IL)-37 expression in tumor tissues was positively associated with the density of tumor-infiltrating CD57+ natural killer (NK) cells, but not with the CD3+ and CD8+ T cells. Consistently, in vitro chemotaxis analysis showed that IL-37-overexpressing hepatocellular carcinoma cells could recruit more NK cells. [Sci Rep] Abstract |