αβT Cell Receptors Expressed by CD4−CD8αβ− Intraepithelial T Cells Drive Their Fate into a Unique Lineage with Unusual MHC Reactivities Researchers used T cell receptor (TCR) sequencing of single cells combined with retrogenic expression of TCRs to study the fate and the major histocompatibility complex (MHC) restriction of double negative TCRαβ+ intraepithelial T cells. [Immunity] Abstract | Graphical Abstract Activated Group 3 Innate Lymphoid Cells Promote T-Cell-Mediated Immune Responses Scientists show that upon IL-1β stimulation, peripheral group 3 innate lymphoid cells become activated, secrete cytokines, up-regulate surface MHC class II molecules, and express costimulatory molecules. [Proc Natl Acad Sci USA] Abstract | Press Release Engager T Cells: A New Class of Antigen-Specific T Cells that Redirect Bystander T Cells Investigators generated T cells expressing a secretable T-cell engager specific for CD3 and EphA2, an antigen expressed on a broad range of human tumors (EphA2-ENG T cells). EphA2-ENG T cells were activated and recognized tumor cells in an antigen-dependent manner, redirected bystander T cells to tumor cells, and had potent antitumor activity in glioma and lung cancer SCID xenograft models associated with a significant survival benefit. [Mol Ther] Abstract Innate Immune Cell CD45 Regulates Lymphopenia-Induced T Cell Proliferation Scientists identify two deficiencies in CD45-RAG1 double-deficient mice that affect lymphopenia-induced proliferation. One involves CD11c+ cells and the second the production of IL-7 by lymphoid stromal cells. [J Immunol] Abstract Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance Scientists explored the immunological regulation of heme oxygenase (HO)-1 in the dextran sulfate sodium-induced model of experimental murine colitis. Further study in vitro revealed that up-regulated HO-1 switched the naive T cells to regulatory T cells (Treg) when cultured under a Th17-inducing environment, which involved in IL-6R blockade. [J Biol Chem] Abstract | Full Article IL-15-Dependent CD8+CD122+ T Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Modulating IL-17 Production by CD4+ T Cells Researchers suggest that interleukin (IL)-15, acting through CD8+CD122+ T cells, has a negative regulatory role in reducing IL-17 production and Th17-mediated experimental autoimmune encephalomyelitis inflammation. [Eur J Immunol] Abstract A B-1a Cell Subset Induces Foxp3− T Cells with Regulatory Activity through an IL-10-Independent Pathway Researchers demonstrate that, similar to the reported B-2 cells, B-1a cells are able to convert naïve CD4+CD25− T cells into a subset of T cells with suppressive function, which they called ‘Treg-of-B1a’ cells. Treg-of-B1a cells do not express Foxp3, but upregulate the regulatory T markers OX40, programmed death 1, inducible costimulator and IL-10R. [Cell Mol Immunol] Abstract Neuroantigen-Specific Autoregulatory CD8+ T Cells Inhibit Autoimmune Demyelination through Modulation of Dendritic Cell Function Investigators show that central nervous system-CD8+ modulate the function of CD11c+ dendritic cells, but not other APCs such as CD11b+ monocytes or B220+ B cells. [PLoS One] Full Article Bystander Activation and Anti-Tumor Effects of CD8+ T Cells following Interleukin-2 Based Immunotherapy Is Independent of CD4+ T Cell Help Utilizing CD4 deficient mouse models, researchers observed a significant expansion of bystander-memory T cells following immunotherapy combining agonistic anti-CD40 and IL-2, which was similar to the non-CD4 depleted mice. [PLoS One] Full Article Subscribe to our sister publications: Human Immunology News and Immunology of Infectious Disease News! |