Immune Regulation News Volume 7.07 | Feb 27 2015

Deltex1 Antagonizes ​HIF-1α and Sustains the Stability of Regulatory T Cells In Vivo
Researchers identified a requirement for ​Deltex1 (​DTX1), a contributor to T-cell anergy and ​Foxp3 protein level maintenance in vivo. ​Dtx1^−/− regulatory T cells (Tregs) are as effective as WT Tregs in the inhibition of ​CD4⁺​CD25⁻ T-cell activation in vitro. However, the suppressive ability of ​Dtx1^−/− Tregs is greatly impaired in vivo. [Nat Commun] Full Article

TGF-β3-Expressing ​CD4⁺​CD25⁻​LAG3⁺ Regulatory T Cells Control Humoral Immune Responses
The authors demonstrate that CD4⁺​CD25⁻​LAG3⁺ regulatory T cells (​LAG3⁺ Treg) produce high amounts of ​TGF-β3 in an ​Egr2⁻ and ​Fas-dependent manner. ​LAG3⁺ Treg require ​TGF-β3 to suppress B-cell responses in a murine model of lupus. [Nat Commun] Full Article

Dendritic Cell SIRT1-HIF1α Axis Programs the Differentiation of CD4⁺ T Cells through IL-12 and TGF-β1
Investigators found that sirtuin 1, a type III histone deacetylase, plays an essential role in mediating proinflammatory signaling in dendritic cells, consequentially modulating the balance of proinflammatory T helper type 1 cells and antiinflammatory Foxp3⁺ regulatory T cells. [Proc Natl Acad Sci USA] Abstract

β-Catenin in Dendritic Cells Exerts Opposite Functions in Cross-Priming and Maintenance of CD8⁺ T Cells through Regulation of IL-10
The authors report that activation of β-catenin in dendritic cells inhibits cross-priming of CD8⁺ T cells by up-regulating mTOR-dependent IL-10, suggesting blocking β-catenin/mTOR/IL-10 signaling as a viable approach to augment CD8⁺ T-cell immunity. [Proc Natl Acad Sci USA] Abstract

IκB_NS Regulates Murine Th17 Differentiation during Gut Inflammation and Infection
Scientists analyzed the role of the unusual inhibitor of NF-κB, IκB_NS, in the proliferation and effector cytokine production of murine Th17 cells. They demonstrated that nuclear IκB_NS is crucial for murine Th17 cell generation. [J Immunol] Abstract

Chitosan Hydrogel Vaccine Generates Protective CD8 T Cell Memory against Mouse Melanoma
Investigators found that vaccination with chitosan hydrogel or dendritic cells using ovalbumin protein as a model antigen and Quil-A adjuvant provided protection in a subcutaneous melanoma challenge 30 days later. [Immunol Cell Biol] Abstract

The Roles of T Helper Type 17/Regulatory T Cells in Acute Rejection after Liver Transplantation in Rats
Scientists investigated the imbalance between T helper type 17 and CD4⁺CD25⁺Foxp3⁺ regulatory T cells during hepatic allograft rejection in a rodent grafts model. [Transplantation] Abstract

Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response against Intracranial Glioma in Mice
The dendritic cell (DC)-derived exosomes (DEXs) generated from DCs loaded with chaperone-rich cell lysates (CRCLs) derived from GL261 glioma cells were found to promote cell proliferation and cytotoxic T lymphocyte activity of CD4⁺ and CD8⁺ T cells in vitro compared with DEX (GL261)-DCs, which were loaded with DEXs derived from DCs loaded with GL261 tumor cell lysates. [J Mol Neurosci] Abstract

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Nodality Inc. Presents Data from Immuno-Oncology Program Applying Company’s Novel Single Cell Network Profiling (SCNP) Platform
Nodality, Inc. announced research results from its lead immuno-oncology efforts based on applications of the company’s SCNP technology. [Press release by Nodality, Inc. discussing research presented at the Molecular Medicine TRI-Conference, San Francisco] Press Release

Advaxis to Present at International Anal Neoplasia Society Scientific Meeting 2015
Advaxis, Inc. announced that an abstract related to ADXS-HPV, the Company’s lead Lm-LLO immunotherapy product candidate, has been selected for oral presentation. [Press release from Advaxis, Inc. discussing research presented at the International Anal Neoplasia Society (IANS) Scientific Meeting 2015, Atlanta] Press Release

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A Novel Immunotherapy Technique to Treat Patients with Osteosarcoma and Neuroblastoma
A novel Phase I clinical trial that leverages T-cell immunotherapy is now under way at Karmanos Cancer Institute and Memorial Sloan-Kettering Cancer Center; bringing new hope to children and young adults with osteosarcoma and neuroblastoma. [Solving Kids’ Cancer] Press Release

Gradalis, Inc. Announces Initiation of a Phase III Registration Study for Vigil™ in Ovarian Cancer
Gradalis Inc. announced that it has initiated a Phase III registration trial for its proprietary autologous immunotherapy, Vigil™, in the treatment of women with stage III/IV ovarian cancer. [Gradalis Inc.] Press Release

ISA Pharmaceuticals Announces Start of First Phase I/II Clinical Trial of Its SLP^®-AMPLIVANT^® Conjugates
ISA Pharmaceuticals B.V. announced the start of an investigator-initiated Phase I/II clinical trial of a novel immunotherapeutic based on ISA Pharmaceuticals´ platform technology. The trial will be conducted by the Department of Clinical Oncology at Leiden University Medical Center in The Netherlands. [ISA Pharmaceuticals B.V.] Press Release

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Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Lecturer – Cancer Immunology (Plymouth University)

Postdoctoral Researcher – Tumor Immunology and Immunotherapy (Cleveland Clinic Lerner Research Institute)

Postdoctoral Associate – Oligonucleotide Aptamer-Based Compounds to Protect Tumor Vaccine-Induced Immune Cells (University of Miami)

Director – Vector Production (Sangamo BioSciences, Inc.)

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Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Postdoctoral Position – HIV and Ebolavirus (University of Missouri)

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