The Receptor TREML4 Amplifies TLR7-Mediated Signaling during Antiviral Responses and Autoimmunity Macrophages from Treml4−/− mice were hyporesponsive to Toll-like receptor 7 (TLR7) agonists and failed to produce type I interferons due to impaired phosphorylation of the transcription factor STAT1 by the mitogen-activated protein kinase p38 and decreased recruitment of the adaptor MyD88 to TLR7. [Nat Immunol] Abstract | Press Release Responsiveness of B Cells Is Regulated by the Hinge Region of IgD The authors suggest that the increased immunoglobulin D (IgD)/IgM ratio on conventional B-2 cells is important for preferential immune responses to antigens in immune complexes, and that the increased IgM expression on B-1 cells is essential for B-1 cell homeostasis and function. [Nat Immunol] Abstract T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses Scientists showed that primary helper follicular T cells segregate into follicular mantle and germinal center subpopulations that display distinct gene expression signatures. [Immunity] Abstract | Graphical Abstract | Press Release Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents Researchers showed that the gut immune system is altered during high-fat diet feeding and is a functional regulator of obesity-related insulin resistance that can be exploited therapeutically. Obesity induces a chronic phenotypic pro-inflammatory shift in bowel lamina propria immune cell populations. [Cell Metab] Full Article | Graphical Abstract | Press Release The Prostaglandin D2 Receptor CRTH2 Regulates Accumulation of Group 2 Innate Lymphoid Cells in the Inflamed Lung The authors provide the first demonstration that expression of the prostaglandin D2 receptor CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) regulates the in vivo accumulation of group 2 innate lymphoid cells in the lung. [Mucosal Immunol] Abstract DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation Scientists demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct natural killer (NK) cell functional subsets: DNAM-1+ and DNAM-1− NK cells. [Cell Rep] Full Article | Graphical Abstract Development of a Cell System for siRNA Screening of Pathogen Responses in Human and Mouse Macrophages To develop an assay platform for high-throughput analysis of macrophage activation by pathogenic stimuli, the authors generated reporter systems in human and mouse macrophages with dynamic readouts for NF-κB and/or TNF-α responses. [Sci Rep] Full Article Conserved and Divergent Aspects of Human T-Cell Development and Migration in Humanized Mice Researchers found that both conventional T-cell development and intra-thymic migration patterns in humanized mice closely resemble human thymopoiesis. They showed that developing human thymocytes engage in short, serial interactions with other human hematopoietic-derived cells. [Immunol Cell Biol] Full Article Macrophages Play an Essential Role in Antigen-Specific Immune Suppression Mediated by T CD8+ Cell-Derived Exosomes Researchers investigated the role of macrophages (Mφ) in T CD8+ suppressor cell-exosome-mediated antigen-specific suppression as well as modulation of Mφ antigen-presenting function in humoral and cellular immunity by suppressive exosomes. [Immunology] Abstract Inhibiting Macrophage Proliferation Suppresses Atherosclerotic Plaque Inflammation Because macrophage proliferation was recently shown to dominate macrophage accumulation in advanced plaques, locally inhibiting macrophage proliferation may reduce plaque inflammation and produce long-term therapeutic benefits. To test this hypothesis, scientists used nanoparticle-based delivery of simvastatin to inhibit plaque macrophage proliferation in apolipoprotein E-deficient mice with advanced atherosclerotic plaques. [Sci Adv] Full Article | Press Release Don’t forget to subscribe to Human Immunology News and Immunology of Infectious Disease News! |