Selective Programming of CCR10+ Innate Lymphoid Cells in Skin-Draining Lymph Nodes for Cutaneous Homeostatic Regulation Researchers found that under steady-state conditions, innate lymphoid cells in skin-draining lymph nodes were continuously activated to acquire regulatory properties and high expression of the chemokine receptor CCR10 for localization into the skin. [Nat Immunol] Abstract CD20+ B Cell Depletion Therapy Suppresses Murine CD8+ T Cell-Mediated Immune Thrombocytopenia (ITP) Scientists investigated the outcome of B cell depletion therapy on CD8+ T cell-mediated ITP using a murine model. CD61 knockout mice were immunized with CD61+ platelets and T cell-mediated ITP was initiated by transfer of their splenocytes into severe combined immunodeficient mice. [Blood] Abstract An Extracatalytic Function of CD45 in B Cells Is Mediated by CD22 Researchers identified a noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor signaling through modulation of the function of the inhibitory coreceptor CD22. [Proc Natl Acad Sci USA] Abstract | Full Article Dendritic Cells Require NIK for CD40-Dependent Cross-Priming of CD8+ T Cells Because NIK (NF-κB–inducing kinase)-deficient mice lack secondary lymphoid organs, scientists generated transgenic mice with targeted NIK deletion in CD11c+ cells. Although these mice exhibited normal lymphoid organs, they were defective in cross-priming naive CD8+ T cells following vaccination, even in the presence of anti-CD40 or polyinosinic:polycytidylic acid to induce dendritic cell maturation. [Proc Natl Acad Sci USA] Abstract | Full Article Super Natural Killer Cells that Target Metastases in the Tumor Draining Lymph Nodes The authors showed that liposomes decorated with apoptosis-inducing ligand TRAIL and an antibody against a mouse natural killer cell marker are carried to the tumor draining inguinal lymph nodes and prevent the lymphatic spread of a subcutaneous tumor in mice. [Biomaterials] Abstract | Press Release MMP-19 Deficiency Causes Aggravation of Colitis Due to Defects in Innate Immune Cell Function The authors explored the role of matrix metalloproteinase (MMP)-19 in IBD pathology. There was a striking delay in neutrophil infiltration into the colon of Mmp-19-deficient (Mmp-19−/−) mice during the acute colitis, leading to persistent inflammation and poor recovery; this was rescued by reconstitution of irradiated Mmp-19−/− mice with wild-type bone marrow. [Mucosal Immunol] Abstract IL-10-Producing CD4+ T Cells Negatively Regulate Fucosylation of Epithelial Cells in the Gut Scientists showed that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. The number of fucosylated epithelial cells was increased in the ileum of mice lacking T cells, especially those expressing αβ T cell receptor, CD4, and IL-10. [Sci Rep] Full Article Uric Acid Enhances the Antitumor Immunity of Dendritic Cell-Based Vaccine Investigators applied uric acid (UA) as an adjuvant to a dendritic cells (DC)-based vaccine, and discovered that the administration of UA as an adjuvant significantly enhanced the ability of the tumor lysate-pulsed DC vaccine in delaying the tumor growth. [Sci Rep] Full Article Don’t forget to subscribe to Human Immunology News and Immunology of Infectious Disease News! |