Immune Regulation News Volume 15.24 | June 30 2023

    By
    Laurisa Dohm
    -
    0
    40








    2023-06-30 | IRN 15.24


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.24 – 30 June, 2023
    TOP STORY

    Gut Microbial Fatty Acid Isomerization Modulates Intraepithelial T Cells

    The authors reported that both dietary factors and microbial factors influenced the level of gut linoleic acid isomers, and that conjugated linoleic acid in turn modulated a distinct population of CD4+ intraepithelial lymphocytes that expressed CD8αα in the small intestine.
    [Nature]

    AbstractPress Release
    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    PUBLICATIONSRanked by the impact factor of the journal

    cGLRs Are a Diverse Family of Pattern Recognition Receptors in Innate Immunity

    Combining structural biology and in vivo analysis in coral and oyster animals, researchers explained how synthesis of distinct nucleotide signals enabled cells to control discrete cGAS-like receptors-STING signaling pathways.
    [Cell]

    Full ArticleGraphical Abstract

    Rewilding of Laboratory Mice Enhances Granulopoiesis and Immunity through Intestinal Fungal Colonization

    Scientists found that tonic signals from fungal colonization induced sustained granulopoiesis through a mechanism distinct from emergency granulopoiesis, leading to a prolonged expansion of circulating neutrophils that promoted immunity.
    [Science Immunology]

    Abstract

    Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling

    Using macrophage-specific Rictor- and mTOR-deficient mice, investigators dissected the distinct functions of mTORC2 pathways in atherogenesis.
    [Circulation Research]

    AbstractFull ArticleGraphical Abstract

    PET Imaging of TREM1 Identifies CNS-Infiltrating Myeloid Cells in a Mouse Model of Multiple Sclerosis

    Researchers validated triggering receptor expressed on myeloid cells 1 (TREM1) as a specific marker of proinflammatory, central nervous system-infiltrating, peripheral myeloid cells in mice with experimental autoimmune encephalomyelitis.
    [Science Translational Medicine]

    Abstract

    Distinct Inflammatory Th17 Subsets Emerge in Autoimmunity and Infection

    Investigators demonstrated that the inflammatory Th17 cells involved in autoimmune colitis and those activated during colitogenic infection were distinguishable populations characterized by their differential responses to the pharmacological molecule, clofazimine.
    [Journal Of Experimental Medicine]

    Abstract

    YTHDF2/m6A/NF-κB Axis Controls Anti-Tumor Immunity by Regulating Intratumoral Tregs

    Scientists discovered that the loss of YTHDF2 in Treg cells reduced tumor growth in mice, and that deletion of Ythdf2 in Tregs did not affect peripheral immune homeostasis, but led to increased apoptosis and impaired suppressive function of Treg cells in the tumor microenvironment.
    [EMBO Journal]

    AbstractGraphical Abstract

    A Bispecific γδ T-Cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T Cell–Mediated Immune Response against EGFR-Expressing Tumors

    An EGFR-Vδ2 bispecific T-cell engager was generated and its capacity to activate Vγ9Vδ2 T cells and trigger antitumor activity were tested in multiple in vitro, in vivo, and ex vivo models.
    [Cancer Immunology Research]

    Abstract

    IKK Promotes Naïve T Cell Survival by Repressing RIPK1-Dependent Apoptosis and Activating NF-κB

    Investigators showed that peripheral naïve T cells in mice required the continued expression of IKK1 and IKK2 for their survival; however, the loss of these cells was only partially prevented when extrinsic cell death pathways were blocked by either deleting Casp8 or inhibiting the kinase activity of RIPK1.
    [Cell Death & Disease]

    Full Article
    Tips to prepare for your next conference or networking event
    REVIEWS

    Post-Transcriptional Checkpoints in Autoimmunity

    The authors summarize current knowledge regarding the roles of post-transcriptional checkpoints in autoimmunity, as evidenced by studies in both hematopoietic and non-hematopoietic cells, and discuss the relevance of these findings for developing new anti-inflammatory therapies.
    [Nature Reviews Rheumatology]

    Abstract

    Targeting Galectin-3 in Inflammatory and Fibrotic Diseases

    Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in several types of inflammatory disorders. Scientists review recent information highlighting Gal-3 as a relevant therapeutic target in specific disease conditions.
    [Trends In Pharmacological Sciences]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    UCB Announces US FDA Approval of RYSTIGGO® for the Treatment of Adults with Generalized Myasthenia Gravis

    RYSTIGGO® is the only FDA-approved treatment in adults for both anti-acetylcholine receptor and anti-muscle-specific tyrosine kinase antibody-positive generalized myasthenia gravis.
    [UCB]

    Press Release
    FEATURED EVENT

    Spotlight on Immuno-Oncology

    August 1 – 2, 2023
    Seattle, Washington, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD positions – Computational Immunology

    Charit̩ Berlin РBerlin, Germany

    Postdoctoral Fellowship – Skin Cancer Metastasis Research & Glycobiology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Researcher – Rheumatoid Arthritis & Chronic Inflammatory Diseases

    Karolinska Institutet – Solna, Sweden

    Research Associate – Innate Lymphoid Cells

    King’s College London – London, England, United Kingdom

    Postdoctoral Fellow – Tumor-Immune Interactions

    NCI Center for Cancer Research – Frederick, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter