 | | Vol. 11.09 – 8 March, 2023 |
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| The authors showed that Nav1.8+ nociceptors signaled to immune cells in the meninges through the neuropeptide calcitonin gene-related peptide during infection. This neuroimmune axis inhibited host defences and exacerbated bacterial meningitis.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that genetic ablation or pharmacological inhibition of mitochondrial pyruvate carrier attenuated severe disease following influenza or SARS-CoV-2 pneumonia.
[Science Immunology] |
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| Researchers demonstrated that a recombinant prefusion-stabilized spike protein vaccine based on Beta/B.1.351 produced a robust anamnestic response in baboons against SARS-CoV-2 variants, when given as a booster one year after immunization with NVX-CoV2373.
[Nature Communications] |
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| The patients’ susceptibility to SARS-CoV-2 could be attributed to impaired TLR7-dependent type I IFN production by plasmacytoid dendritic cells, which did not sense SARS-CoV-2 correctly.
[Journal Of Experimental Medicine] |
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| Single-cell transcriptomics of lungs of patients with long COVID revealed a unique immune signature demonstrating the upregulation of key proinflammatory and innate immune effector genes CD47, IL-6, and JUN.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators revealed vitamin C (VitC) administration was a potent strategy to prevent SARS-CoV-2 infection. VitC reduced ACE2 protein levels in a dose-dependent manner, while even a partial reduction in ACE2 levels could greatly inhibit SARS-CoV-2 infection.
[EMBO Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists demonstrated that Candida albicans-specific T helper 17 (Th17) cells were increased in circulation and present in the liver of patients with alcohol-associated liver disease. Chronic ethanol administration in mice caused migration of C. albicans-reactive Th17 cells from the intestine to the liver.
[Cell Host & Microbe] |
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| Researchers identified a single nucleotide polymorphism in the non-coding region of the S100A10 (p11) gene that affected mRNA and protein expression in response to A. fumigatus and was associated with protection against invasive pulmonary aspergillosis.
[Cell Host & Microbe] |
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| Topical keratin 6a–derived antimicrobial peptides treatment effectively alleviated experimental bacterial keratitis, as evidenced by substantial reductions of corneal opacification, inflammatory cell infiltration, and bacterial burden.
[Science Translational Medicine] |
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| A mRNA-LNP vaccine elicited humoral and cellular immunological responses in C57BL/6 mice and conferred rapid, full protection against lethal Y. pestis infection after a single dose.
[Science Advances] |
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| Based on the systematic review and meta-analysis of randomized controlled trials, the efficacy of SARS-CoV-2 vaccines is higher for preventing severe infection and death than for preventing milder infection. Vaccine efficacy wanes over time but can be enhanced by a booster.
[Lancet Microbe] |
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| The authors review 15 autosomal-dominant or -recessive inborn errors of immunity involving 11 transcription factors and impairing interferon-gamma immunity, conferring a predisposition to mycobacterial diseases.
[Current Opinion In Immunology] |
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| Invivyd announced the selection of a candidate called VYD222 to move forward into the clinic, at the expense of previous focus NVD200, according to a press release. The new star in the company’s pipeline is one of the components of the older treatment and was also engineered from the original mAb adintrevimab.
[Fierce Biotech] |
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| April 23 – 26, 2023
Snowbird, Utah, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Karolinska Institutet – Solna, Sweden |
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| | The University of Melbourne – Melbourne, Australia |
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| | Twincore GmbH – Hannover, Germany |
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| | The University of Konstanz – Konstanz, Germany |
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