Immunology of Infectious Disease News | Sep 28 2022

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    2022-09-28 | IIDN 10.38


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 10.38 – 28 September, 2022
    TOP STORY

    Mucosal Plasma Cells Are Required To Protect the Upper Airway and Brain from Infection

    Plasma cell depletions demonstrated that plasma cells must reside within olfactory tissue to achieve sterilizing immunity. Antibody blockade and genetically deficient models revealed that this local immunity required CD4+ T cells and CXCR3.
    [Immunity]

    AbstractGraphical AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Memory B Cell Responses to Omicron Subvariants After SARS-CoV-2 mRNA Breakthrough Infection in Humans

    Scientists examined the memory antibodies that develop after a third or fourth antigenic exposure by Delta or Omicron BA.1 infection, respectively.
    [Journal of Experimental Medicine]

    Full Article

    Design and Lyophilization of Lipid Nanoparticles for mRNA Vaccine and Its Robust Immune Response in Mice and Nonhuman Primates

    Buffer optimization allowed the determination of lyophilization conditions, where lipid nanoparticle-encapsulated mRNA encoding SARS-CoV-2 spike protein could induce robust immunogenicity in mice after one month of storage at 5°C and 25°C.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study To Evaluate the Efficacy and Safety of Camostat Mesilate in Patients with COVID-19 (CANDLE Study)

    Researchers investigated whether camostat mesilate is an effective treatment for SARS-CoV-2 infection. This was a multicenter, double-blind, randomized, parallel-group, placebo-controlled study.
    [BMC Medicine]

    Full Article

    Cross-Reactivity of SARS-CoV-2– and Influenza A–Specific T Cells in Individuals Exposed to SARS-CoV-2

    The authors analyzed whether exposure to influenza A virus antigens could influence the T cell repertoire in response to SARS-CoV-2, indicating a heterologous immune response between these 2 unrelated viruses.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Inactivated Rabies-Vectored SARS-CoV-2 Vaccine Provides Long-Term Immune Response Unaffected by Vector Immunity

    Scientists screened adjuvants for the highest quality antibody titers, negated the concern of pre-existing rabies-vector immunity, and established its potential as a long-term COVID-19 vaccine.
    [NPJ Vaccines]

    Full Article

    Asymptomatic or Symptomatic SARS-CoV-2 Infection Plus Vaccination Confers Increased Adaptive Immunity to Variants of Concern

    In this cross-sectional study, researchers examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier.
    [iScience]

    AbstractGraphical Abstract

    Omicron Neutralizing Antibody Response following Booster Vaccination Compared with Breakthrough Infection

    Investigators analyzed spike receptor-binding domain-specific IgG, IgA, and IgM by enzyme-linked immunosorbent assay, neutralizing antibody titers against live SARS-CoV-2 variants, and antibody-depended cell-mediated phagocytosis in 99 randomly selected individuals.
    [Med]

    AbstractFull ArticleGraphical Abstract

    Maternally Transferred mAbs Protect Neonatal Mice From HSV-Induced Mortality and Morbidity

    Scientists tested the hypothesis that passive transfer of herpes simplex virus (HSV)-specific human mAbs can prevent mortality and morbidity associated with neonatal HSV.
    [Journal of Experimental Medicine]

    Abstract

    Directly Injected Lentiviral Vector–Based T Cell Vaccine Protects Mice Against Acute and Chronic Viral Infection

    Injection of a lentiviral vector encoding an MHC class I–restricted T cell epitope of lymphocytic choriomeningitis virus and CD40 ligand induced an antigen-specific cytolytic CD8+ T lymphocyte response that protected the mice from infection.
    [JCI Insight]

    Full Article

    MicroRNAs Combined With the TLR4/TDAG8 mRNAs and Proinflammatory Cytokines Are Biomarkers for the Rapid Diagnosis of Sepsis

    To obtain novel biomarkers that serve as prompt indicators of sepsis, the current study screened the differentially expressed microRNAs that were associated with sepsis susceptibility.
    [Molecular Medicine Reports]

    Full Article
    Five tips for returning to the lab after time off
    REVIEWS

    Pathogenesis of Zika Virus Infection

    The authors discuss recent reports on the mechanisms used by Zika virus to replicate efficiently, and they highlight potential new areas of research for the development of therapeutic approaches.
    [Annual Review of Pathology-Mechanisms of Disease]

    Abstract
    INDUSTRY AND POLICY NEWS

    Pfizer Announces Positive Top-Line Results from Phase III Study in 20-Valent Pneumococcal Conjugate Vaccine in Infants in the European Union

    Pfizer announced positive top-line results from its pivotal EU Phase III study in infants evaluating its 20-valent pneumococcal conjugate vaccine candidate for the prevention of invasive pneumococcal disease, pneumonia, and acute otitis media.
    [Pfizer]

    Press Release

    InnoCare Announces Approval of Clinical Trial of BCL2 Inhibitor ICP-248 in China

    InnoCare Pharma announced that the Company has received Investigational New Drug approval of clinical trial from the National Medical Products Administration for its B cell lymphoma-2 inhibitor ICP-248.
    [InnoCare Pharma]

    Press Release
    FEATURED EVENT

    SInfection Prevention and Control Canada 2023 National Education Conference

    May 28-31, 2023
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Chronic Lung Disease and HIV

    The University of British Columbia – Vancouver, British Columbia, Canada

    Canada Research Chair- Systems Immunology

    University of Calgary – Calgary, Alberta, Canada

    PhD Fellowship – Intestinal Microbiology

    University of Stavanger – Stavanger, Norway

    Physician Scientist – Infectious Disease

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    Postdoctoral Research Scientist – Epithelial Plasticity and Virulence in Lung Adenocarcinoma

    CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom

    > See All Jobs

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